ArticleThe EMBO journal2010
Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 74 citations in OpenAlex.
- Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality.Protein science : a publication of the Protein Society · 2026Review
- The mitochondrial proteome of diplonemids: from conventional pathways to eccentric RNA editing and transcript processing.BMC genomics · 2025Article
- SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila.PLoS biology · 2024Article
- Review
- Mitochondrial Porin Is Involved in Development, Virulence, and Autophagy inJournal of fungi (Basel, Switzerland) · 2022Article
- Coordination of metal center biogenesis in human cytochrome c oxidase.Nature communications · 2022Article
- Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation.Frontiers in oncology · 2022Article
- Pathways shaping the mitochondrial inner membrane.Open biology · 2021Review
- Studying Lipid-Related Pathophysiology Using the Yeast Model.Frontiers in physiology · 2021Review
- Molecular mechanism of mitochondrial phosphatidate transfer by Ups1.Communications biology · 2020Article
- Phospholipid ebb and flow makes mitochondria go.The Journal of cell biology · 2020Review
- Article
- Proteolytic Control of Lipid Metabolism.ACS chemical biology · 2019Review
- Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.Nature communications · 2019Article
- Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport.Cell reports · 2019Article
- Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast.The Journal of biological chemistry · 2018Article
- Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae.Scientific reports · 2017Article
- Multitiered and Cooperative Surveillance of Mitochondrial Phosphatidylserine Decarboxylase 1.Molecular and cellular biology · 2017Article
- AEMBO reports · 2017Article
- A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro.Scientific reports · 2016Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Ups1p, Ups2p, and Ups3p are three homologous proteins that control phospholipid metabolism in the mitochondrial intermembrane space (IMS). The Ups proteins are atypical IMS proteins in that they lack the two major IMS-targeting signals, bipartite presequences and cysteine motifs. Here, we show that Ups protein import is mediated by another IMS protein, Mdm35p. In vitro import assays show that import of Ups proteins requires Mdm35p. Loss of Mdm35p led to a decrease in steady state levels of Ups proteins in mitochondria. In addition, mdm35Delta cells displayed a similar phenotype to ups1Deltaups2Deltaups3Delta cells. Interestingly, unlike typical import machineries, Mdm35p associated stably with Ups proteins at a steady state after import. Demonstrating that Mdm35p is a functional component of Ups-Mdm35p complexes, restoration of Ups protein levels in mdm35Delta mitochondria failed to restore phospholipid metabolism. These findings provide a novel mechanism in which the formation of functional protein complexes drives mitochondrial protein import.
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