ArticleCell adhesion & migration
Neural circuit formation in the cerebellum is controlled by cell adhesion molecules of the Contactin family.
Article in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Delayed astrocyte development impairs Sema6a-Plxna2/4-mediated astrocyte-neuron crosstalk and causes depressive-like behavior.Nature communications · 2026Article
- Article
- Role of CNTN6 in neurodevelopment and neuropathology.Frontiers in neuroscience · 2026Review
- The Nuclear Transitory Zone: A Key Player in the Cerebellar Development.Cerebellum (London, England) · 2025Review
- Stepwise molecular specification of excitatory synapse diversity onto cerebellar Purkinje cells.Nature neuroscience · 2025Article
- Contactin proteins in cerebrospinal fluid show different alterations in dementias.Journal of neurology · 2024Article
- Molecular mechanism of contactin 2 homophilic interaction.Structure (London, England : 1993) · 2024Article
- The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts.International journal of molecular sciences · 2023Review
- Fluid markers of synapse degeneration in synucleinopathies.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Endoglycan Regulates Purkinje Cell Migration by Balancing Cell-Cell Adhesion.Frontiers in neuroscience · 2022Article
- Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex.Frontiers in neuroscience · 2021Article
- Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology.Pharmacological reviews · 2019Review
- Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.Cellular and molecular neurobiology · 2019Article
- Contactins in the central nervous system: role in health and disease.Neural regeneration research · 2019Review
- Modulation of Nerve Cell Differentiation: Role of Polyphenols and of Contactin Family Components.Frontiers in cell and developmental biology · 2019Article
- Article
- Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.Alzheimer's research & therapy · 2018Article
- Unexpected phenotypic effects of a transgene integration causing a knockout of the endogenous Contactin-5 gene in mice.Transgenic research · 2018Article
- CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders.Molecular psychiatry · 2017Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell adhesion molecules of the immunoglobulin superfamily (IgSF CAMs) have been implicated in neural circuit formation in both the peripheral and the central nervous system. Several recent studies highlight a role of the Contactin group of IgSF CAMs in cerebellar development, in particular in the development of granule cells. Granule cells are the most numerous type of neurons in the nervous system and by forming a secondary proliferative zone in the cerebellum they provide an exception to the rule that neuronal precursors proliferate in the ventricular zone. Granule cells express Contactin-2, Contactin-1, and Contactin-6 in a sequential manner. Contactins are required for axon guidance, fasciculation, and synaptogenesis, and thus affect multiple steps in neural circuit formation in the developing cerebellum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.