ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Arrhythmogenesis by single ectopic beats originating in the Purkinje system.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Prediction of arrhythmogenesis in non-ischemic cardiac resynchronization therapy patients.APL bioengineering · 2026Article
- Mechanism of Arrhythmogenesis Driven by Early After Depolarizations in Cardiac Tissue.PLoS computational biology · 2025Article
- Editorial: Advancing our understanding of the cardiac conduction system to prevent arrhythmias.Frontiers in physiology · 2025Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome.PloS one · 2024Article
- Two-to-one Purkinje-to-myocardium activation during ventricular fibrillation associated with hypertrophic cardiomyopathy.HeartRhythm case reports · 2023Article
- Long-term freedom from ventricular fibrillation despite persistent Purkinje ectopy after catheter ablation.HeartRhythm case reports · 2022Article
- Electrocardiographic Characteristics and Catheter Ablation of Ventricular Arrhythmias Originating From the Moderator Band in Children.Frontiers in pediatrics · 2022Article
- Whole-heart ventricular arrhythmia modeling moving forward: Mechanistic insights and translational applications.Biophysics reviews · 2021Article
- The Case of an Asymptomatic Athlete With Short-Coupled Premature Ventricular Contractions: A Missed Opportunity.JACC. Case reports · 2021Article
- Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities.Journal of molecular and cellular cardiology · 2020Article
- Delayed afterdepolarization-induced triggered activity in cardiac purkinje cells mediated through cytosolic calcium diffusion waves.Physiological reports · 2019Article
- Idiopathic ventricular fibrillation with repetitive activity inducible within the distal Purkinje system.Heart rhythm · 2019Article
- A comprehensive, multiscale framework for evaluation of arrhythmias arising from cell therapy in the whole post-myocardial infarcted heart.Scientific reports · 2019Article
- Unsolved Questions on the Anatomy of the Ventricular Conduction System.Korean circulation journal · 2018Review
- Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.Progress in biophysics and molecular biology · 2016Review
- Ventricular arrhythmias and the His-Purkinje system.Nature reviews. Cardiology · 2016Review
- Article
- Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load.Cardiovascular research · 2015Article
- Optical mapping of optogenetically shaped cardiac action potentials.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Cells in the Purkinje system (PS) are known to be more vulnerable than ventricular myocytes to secondary excitations during the action potential (AP) plateau or repolarization phases, known as early afterdepolarizations (EADs). Since myocytes have a lower intrinsic AP duration than the PS cells to which they are coupled, EADs occurring in distal branches of the PS are more likely to result in propagating ectopic beats. In this study, we use a computer model of the rabbit ventricles and PS to investigate the consequences of EADs occurring at different times and places in the cardiac conduction system. We quantify the role of tissue conductivity and excitability, as well as interaction with sinus excitation, in determining whether an EAD-induced ectopic beat will establish reentrant activity. We demonstrate how a single ectopic beat arising from an EAD in the distal PS can give rise to reentrant arrhythmia; in contrast, EADs in the proximal PS were unable to initiate reentry. Clinical studies have established the PS as a potential substrate for reentry, but the underlying mechanisms of these types of disorder are not well understood, nor are conditions leading to their development clearly defined; this work provides new insights into the role of the PS in such circumstances. Our findings indicate that simulated EADs in the distal PS can induce premature beats, which can lead to the tachycardias involving the conduction system due to interactions with sinus activity or impaired myocardial conduction velocity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.