ArticleAmerican journal of respiratory and critical care medicine2010
Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus.
Article in American journal of respiratory and critical care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Obstructive Sleep Apnea and Arrhythmia: A Narrative Review of Arrhythmogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2026Review
- Noradrenergic input to hypoglossal motoneurons is mediated by interneurons located in prehypoglossal region.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Dexmedetomidine regulates sleep rhythm and alleviates neuroinflammation in rats under high-altitude hypoxia.Journal of physiology and biochemistry · 2025Article
- Chronic intermittent hypoxia attenuates noradrenergic innervation of hypoglossal motor nucleus.Respiratory physiology & neurobiology · 2024Article
- Prevalence and factors associated with atrial fibrillation in older patients with obstructive sleep apnea.BMC geriatrics · 2022Article
- Role of raphe magnus 5-HTRespiratory research · 2022Article
- Brain tissue integrity mapping in adults with obstructive sleep apnea using T1-weighted and T2-weighted images.Therapeutic advances in neurological disorders · 2022Article
- Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.Experimental neurology · 2022Article
- The dorsal and the ventral side of hypoglossal motor nucleus showed different response to chronic intermittent hypoxia in rats.Sleep & breathing = Schlaf & Atmung · 2021Article
- Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions.Psychopharmacology · 2021Article
- Brown Adipose Tissue Activation Is Involved in Atherosclerosis of ApoEFrontiers in cardiovascular medicine · 2021Article
- Noradrenergic terminal density varies among different groups of hypoglossal premotor neurons.Journal of chemical neuroanatomy · 2019Article
- Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.Journal of cellular physiology · 2019Article
- Increased tongue use enhances 5-HTRespiratory physiology & neurobiology · 2019Article
- Hypoglossal motoneurons are endogenously activated by serotonin during the active period of circadian cycle.Respiratory physiology & neurobiology · 2018Article
- Effect of Gender on Chronic Intermittent HypoxicFrontiers in physiology · 2018Article
- Neuroanatomical Basis of State-Dependent Activity of Upper Airway Muscles.Frontiers in neurology · 2018Review
- Catecholaminergic A1/C1 neurons contribute to the maintenance of upper airway muscle tone but may not participate in NREM sleep-related depression of these muscles.Respiratory physiology & neurobiology · 2017Article
- Chronic intermittent hypoxia affects endogenous serotonergic inputs and expression of synaptic proteins in rat hypoglossal nucleus.American journal of translational research · 2017Article
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationalePatients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness. Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory drive to upper airway motoneurons. In patients with OSA, this drive is necessary to maintain their upper airway open. We tested whether chronic intermittent hypoxia (CIH), a major pathogenic factor of OSA, affects aminergic innervation of XII motoneurons that innervate tongue-protruding muscles in a manner that could alter their airway-dilatory action.
objectivesTo determine the impact of CIH on neurochemical markers of NE and 5-HT innervation of the XII nucleus.
methodsNE and 5-HT terminal varicosities and α₁-adrenergic and 5-HT₂A receptors were immunohistochemically visualized and quantified in the XII nucleus in adult rats exposed to CIH or room air exchanges for 10 h/d for 34 to 40 days. MEASUREMENTS AND MAIN
resultsCIH-exposed rats had approximately 40% higher density of NE terminals and approximately 20% higher density of 5-HT terminals in the ventromedial quadrant of the XII nucleus, the region that controls tongue protruder muscles, than sham-treated rats. XII motoneurons expressing α₁-adrenoceptors were also approximately 10% more numerous in CIH rats, whereas 5-HT₂A receptor density tended to be lower in CIH rats.
conclusionsCIH-elicited increase of NE and 5-HT terminal density and increased expression of α₁-adrenoceptors in the XII nucleus may lead to augmentation of endogenous aminergic excitatory drives to XII motoneurons, thereby contributing to the increased upper airway motor tone in patients with OSA.
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