ArticleThe Journal of biological chemistry2010
A chromatin-remodeling protein is a component of fission yeast mediator.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Cyclin C influences the timing of mitosis in fission yeast.Molecular biology of the cell · 2017Article
- EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation.Molecular cell · 2016Article
- Post-translational modifications of histones that influence nucleosome dynamics.Chemical reviews · 2015Review
- Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions.Epigenetics & chromatin · 2015Article
- A functional portrait of Med7 and the mediator complex in Candida albicans.PLoS genetics · 2014Article
- Mechanisms of Mediator complex action in transcriptional activation.Cellular and molecular life sciences : CMLS · 2013Review
- The Mediator complex and transcription elongation.Biochimica et biophysica acta · 2013Review
- CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S. pombe.The EMBO journal · 2012Article
- Mediator regulates non-coding RNA transcription at fission yeast centromeres.Epigenetics & chromatin · 2012Article
- Mediator promotes CENP-a incorporation at fission yeast centromeres.Molecular and cellular biology · 2012Article
- Mediator complex regulates alternative mRNA processing via the MED23 subunit.Molecular cell · 2012Article
- A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast.PLoS genetics · 2012Article
- The Mediator complex and transcription regulation.Critical reviews in biochemistry and molecular biologyReview
- Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multiprotein Mediator complex is an important regulator of RNA polymerase II-dependent genes in eukaryotic cells. In contrast to the situation in many other eukaryotes, the conserved Med15 protein is not a stable component of Mediator isolated from fission yeast. We here demonstrate that Med15 exists in a protein complex together with Hrp1, a CHD1 ATP-dependent chromatin-remodeling protein. The Med15-Hrp1 subcomplex is not a component of the core Mediator complex but can interact with the L-Mediator conformation. Deletion of med15(+) and hrp1(+) causes very similar effects on global steady-state levels of mRNA, and genome-wide analyses demonstrate that Med15 associates with a distinct subset of Hrp1-bound gene promoters. Our findings therefore indicate that Mediator may directly influence histone density at regulated promoters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.