ArticleMolecular biology and evolution2010
Demosponge EST sequencing reveals a complex genetic toolkit of the simplest metazoans.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A sponge homolog of BRMS1 reveals ancient origin of metastasis-suppressing functions.BMC biology · 2026Article
- The origin and evolution of Wnt signalling.Nature reviews. Genetics · 2024Review
- The ancestral type of the R-RAS protein has oncogenic potential.Cellular & molecular biology letters · 2024Article
- Transfection of Sponge Cells and Intracellular Localization of Cancer-Related MYC, RRAS2, and DRG1 Proteins.Marine drugs · 2023Article
- Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans.Scientific reports · 2022Article
- First insight of genetic diversity, phylogeographic relationships, and population structure of marine spongeEcology and evolution · 2022Article
- Review
- Comparative Genomics Reveals Pathogenicity-Related Loci inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2020Article
- Article
- A survey of metastasis suppressors in Metazoa.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Sponges: A Reservoir of Genes Implicated in Human Cancer.Marine drugs · 2018Review
- An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune and apoptotic pathways.Biochemistry and biophysics reports · 2017Article
- Comparative transcriptome analysis reveals insights into the streamlined genomes of haplosclerid demosponges.Scientific reports · 2016Article
- Article
- Nme family of proteins--clues from simple animals.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- A therapeutic potential for marine skeletal proteins in bone regeneration.Marine drugs · 2013Review
- Transcriptome profiling of the demosponge Amphimedon queenslandica reveals genome-wide events that accompany major life cycle transitions.BMC genomics · 2012Article
- Structural and functional characterization of ribosomal protein gene introns in sponges.PloS one · 2012Article
- Virtual genomes in flux: an interplay of neutrality and adaptability explains genome expansion and streamlining.Genome biology and evolution · 2012Article
- Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sponges (Porifera) are among the simplest living and the earliest branching metazoans. They hold a pivotal role for studying genome evolution of the entire metazoan branch, both as an outgroup to Eumetazoa and as the closest branching phylum to the common ancestor of all multicellular animals (Urmetazoa). In order to assess the transcription inventory of sponges, we sequenced expressed sequence tag libraries of two demosponge species, Suberites domuncula and Lubomirskia baicalensis, and systematically analyzed the assembled sponge transcripts against their homologs from complete proteomes of six well-characterized metazoans--Nematostella vectensis, Caenorhabditis elegans, Drosophila melanogaster, Strongylocentrotus purpuratus, Ciona intestinalis, and Homo sapiens. We show that even the earliest metazoan species already have strikingly complex genomes in terms of gene content and functional repertoire and that the rich gene repertoire existed even before the emergence of true tissues, therefore further emphasizing the importance of gene loss and spatio-temporal changes in regulation of gene expression in shaping the metazoan genomes. Our findings further indicate that sponge and human genes generally show similarity levels higher than expected from their respective positions in metazoan phylogeny, providing direct evidence for slow rate of evolution in both "basal" and "apical" metazoan genome lineages. We propose that the ancestor of all metazoans had already had an unusually complex genome, thereby shifting the origins of genome complexity from Urbilateria to Urmetazoa.
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