ArticleAnnals of internal medicine2010
Sexually transmitted diseases among users of erectile dysfunction drugs: analysis of claims data.
Article in Annals of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 84 citations in OpenAlex.
- Case Report: Resolution of high grade anal squamous intraepithelial lesion with antibiotics proposes a new role for syphilitic infection in potentiation of HPV-associated ASCC.Frontiers in oncology · 2023Article
- Erectile Dysfunction Medication Prescription: STI and Risk Behavior in Men with HIV.The journal of sexual medicine · 2019Article
- Influences of Economic, Social and Cultural Marginalization on the Association Between Alcohol Use and Sexual Risk Among Formerly Incarcerated Latino Men.Journal of immigrant and minority health · 2017Article
- Sinecatechins Ointment, 15% for the Treatment of External Genital and Perianal Warts: Proceedings of an Expert Panel Roundtable Meeting.The Journal of clinical and aesthetic dermatology · 2016Article
- Incidence of sexually transmitted infections after human papillomavirus vaccination among adolescent females.JAMA internal medicine · 2015Article
- Care of the human immunodeficiency virus-infected menopausal woman.American journal of obstetrics and gynecology · 2012Review
- Article
- Sexual dysfunction, HIV, and AIDS in men who have sex with men.AIDS patient care and STDs · 2011Article
- HIV, Sexually Transmitted Infections, and Sexuality in Later Life.Current infectious disease reports · 2011Article
- Does erectile dysfunction drug use contribute to risky sexual behavior?Asian journal of andrology · 2010Article
- Novel erectile analyses revealed augmentable penile Lyve-1, the lymphatic marker, expression.Reproductive medicine and biologyArticle
- Sexually transmitted infections in the elderly: A growing concern in geriatric care.Indian journal of sexually transmitted diseases and AIDSReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPharmacologic treatments for erectile dysfunction (ED) have gained popularity among middle-aged and older men. Increased sexual activity among those who use these drugs raises concerns about sexually transmitted diseases (STDs).
objectiveTo examine the rates of STDs in men who use and do not use ED drugs.
designRetrospective cohort study.
settingDatabase of claims from 1997 to 2006 for 1,410,806 men older than age 40 years with private, employer-based insurance from 44 large companies. PATIENTS: 33,968 men with at least 1 filled prescription for an ED drug and 1,376,838 patients with no prescription. MEASUREMENTS: STD prevalence among users and nonusers of ED drugs.
resultsUsers of ED drugs had higher rates of STDs than nonusers the year before initiating ED drug therapy (214 vs. 106 annually per 100,000 persons; P = 0.003) and the year after (105 vs. 65; P = 0.004). After adjustment for age and other comorbid conditions, users of ED drugs had an odds ratio (OR) for an STD of 2.80 (95% CI, 2.10 to 3.75) in the year before initiating drug therapy; the OR was 2.65 (CI, 1.84 to 3.81) in the year after. These differences were largely due to infections with HIV. The OR for HIV infection was 3.32 (CI, 2.38 to 4.36) in the year before and 3.19 (CI, 2.11 to 4.83) in the year after an ED drug prescription was filled. Significant changes in STD rates from the year before to the year after the first ED drug prescription was filled were not documented (adjusted OR for STD for users before vs. after the first ED drug prescription was filled, 0.96 [CI, 0.87 to 1.06]). LIMITATION: Selection bias precludes conclusions about whether use of ED treatments directly leads to increases in STDs.
conclusionMen who use ED drugs have higher rates of STDs, particularly HIV infection, both in the year before and after use of these drugs. The observed association between ED drug use and STDs may have more to do with the types of patients using ED drugs rather than a direct effect of ED drug availability on STD rates. Counseling about safe sexual practices and screening for STDs should accompany the prescription of ED drugs. PRIMARY FUNDING SOURCE: RAND Roybal Center, National Institutes of Health, and Agency for Healthcare Research and Quality.
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