ArticleMolecular and cellular neurosciences2010
The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway.
Article in Molecular and cellular neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- A spinal neural circuitry for converting touch to itch sensation.Nature communications · 2020Article
- Altered expression of target genes of spinal cord in different itch models compared with capsaicin assessed by RT-qPCR validation.Oncotarget · 2017Article
- Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A microdeletion of chromosome 9q33.3 encompasses the entire LMX1B gene in a Chinese family with nail patella syndrome.International journal of molecular sciences · 2014Article
- Null mutations of NT-3 and Bax affect trigeminal ganglion cell number but not brainstem barrelette pattern formation.Somatosensory & motor research · 2013Article
- Development of the principal nucleus trigeminal lemniscal projections in the mouse.The Journal of comparative neurology · 2013Article
- A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord.PloS one · 2013Article
- Development and critical period plasticity of the barrel cortex.The European journal of neuroscience · 2012Review
- The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex.Somatosensory & motor research · 2012Article
- Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- How do barrels form in somatosensory cortex?Annals of the New York Academy of Sciences · 2011Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known of transcriptional mechanisms underlying the development of the trigeminal (V) principal sensory nucleus (PrV), the brainstem nucleus responsible for the development of the whisker-to-barrel cortex pathway. Lmx1b, a LIM homeodomain transcription factor, is expressed in embryonic PrV. In Lmx1b knockout ((-)(/)(-)) mice, V primary afferent projections to PrV are normal, albeit reduced in number, whereas the PrV-thalamic lemniscal pathway is sparse and develops late. Excess cell death occurs in the embryonic Lmx1b(-)(/)(-) PrV, but not in Lmx1b/Bax double null mutants. Expression of Drg11, a downstream transcription factor essential for PrV development and pattern formation, is abolished in PrV, but not in the V ganglion. Consequently, whisker patterns fail to develop in PrV by birth. Rescued PrV cells in Lmx1b/Bax double (-)(/)(-)s failed to rescue whisker-related PrV pattern formation. Thus, Lmx1b and Drg11 may act in the same genetic signaling pathway that is essential for PrV pattern formation.
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