ArticleGastroenterology2010
Therapeutic liver reconstitution with murine cells isolated long after death.
Article in Gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Multi-Omics Investigation into Why Viable Oogonial Stem Cells Can Still Be Isolated and Cultured from Post-MortemInternational journal of molecular sciences · 2025Article
- Apoptosis in Postmortal Tissues of Goat Spinal Cords and Survival of Resident Neural Progenitors.International journal of molecular sciences · 2024Article
- Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice.Scientific reports · 2023Article
- NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.Hepatology (Baltimore, Md.) · 2021Article
- Bovine Satellite Cells Isolated after 2 and 5 Days of Tissue Storage Maintain the Proliferative and Myogenic Capacity Needed for Cultured Meat Production.International journal of molecular sciences · 2021Article
- Cadaveric Stem Cells: Their Research Potential and Limitations.Frontiers in genetics · 2021Review
- Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.Stem cell reports · 2017Article
- Cadaveric cardiosphere-derived cells can maintain regenerative capacity and improve the heart function of cardiomyopathy.Cell cycle (Georgetown, Tex.) · 2016Article
- Hepatic progenitor cells of biliary origin with liver repopulation capacity.Nature cell biology · 2015Article
- Recovery of fibroblast-like cells from refrigerated goat skin up to 41 d of animal death.In vitro cellular & developmental biology. Animal · 2015Article
- Therapeutic hepatocyte transplant for inherited metabolic disorders: functional considerations, recent outcomes and future prospects.Journal of inherited metabolic disease · 2014Review
- Intestinal stem cells remain viable after prolonged tissue storage.Cell and tissue research · 2013Article
- Effect of postmortem time interval on in vitro culture potential of goat skin tissues stored at room temperature.In vitro cellular & developmental biology. Animal · 2012Article
- Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity.Nature communications · 2012Article
- Molecular perturbations restrict potential for liver repopulation of hepatocytes isolated from non-heart-beating donor rats.Hepatology (Baltimore, Md.) · 2012Article
- In vitro culture of fibroblast-like cells from postmortem skin of Katahdin sheep stored at 4 °C for different time intervals.In vitro cellular & developmental biology. Animal · 2011Article
- Management of Liver Failure: From Transplantation to Cell-Based Therapy.Cell medicine · 2011Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsDue to the shortage of donor organs, many patients needing liver transplantation cannot receive one. For some liver diseases, hepatocyte transplantation could be a viable alternative, but donor cells currently are procured from the same sources as whole organs, and thus the supply is severely limited.
methodsHere, we investigated the possibility of isolating viable hepatocytes for liver cell therapy from the plentiful source of morgue cadavers. To determine the utility of this approach, cells were isolated from the livers of non-heart-beating cadaveric mice long after death and transplanted into fumarylacetoacetate hydrolase-deficient mice, a model for the human metabolic liver disease hereditary tyrosinemia type I and a stringent in vivo model for hepatic cell transplantation.
resultsSurprisingly, complete and therapeutic liver repopulation could be achieved with hepatocytes derived up to 27 hours post mortem.
conclusionsCompetitive repopulation experiments showed that cadaveric liver cells had a repopulation capacity similar to freshly isolated hepatocytes. Importantly, viable hepatocytes also could be isolated from cadaveric primate liver (monkey and human) efficiently. These data provide evidence that non-heart-beating donors could be a suitable source of hepatocytes for much longer time periods than previously thought possible.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.