ReviewHeart rhythm2010
Forward trafficking of ion channels: what the clinician needs to know.
Review in Heart rhythm, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Article
- Unravelling the human taste receptor interactome: machine learning and molecular modelling insights into protein-protein interactions.NPJ science of food · 2025Article
- Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024Review
- Functional tuning of Vascular L-type CaFrontiers in physiology · 2022Review
- Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes.Basic research in cardiology · 2021Article
- Virtual cardiac monolayers for electrical wave propagation.Scientific reports · 2017Article
- Localisation Microscopy of Breast Epithelial ErbB-2 Receptors and Gap Junctions: Trafficking after γ-Irradiation, Neuregulin-1β, and Trastuzumab Application.International journal of molecular sciences · 2017Article
- The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking.Biochimica et biophysica acta · 2016Review
- Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium.Circulation. Arrhythmia and electrophysiology · 2016Review
- Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes.Journal of computational neuroscience · 2016Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2.Toxicon : official journal of the International Society on Toxinology · 2014Article
- Autoregulation of connexin43 gap junction formation by internally translated isoforms.Cell reports · 2013Article
- L-type calcium channel targeting and local signalling in cardiac myocytes.Cardiovascular research · 2013Review
- BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.Heart rhythm · 2012Article
- Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane.Circulation research · 2012Article
- The gap junction life cycle.Heart rhythm · 2012Article
- A novel strategy using cardiac sodium channel polymorphic fragments to rescue trafficking-deficient SCN5A mutations.Circulation. Cardiovascular genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Each heartbeat requires precisely orchestrated action potential propagation through the myocardium, achieved by coordination of about a million ion channels on the surface of each cardiomyocyte. Specific ion channels must occur within discrete subdomains of the sarcolemma to exert their electrophysiological effects with highest efficiency (e.g., voltage-gated Ca(2+) channels at T-tubules and gap junctions at intercalated discs). Regulation of ion channel movement to their appropriate membrane subdomain is an exciting research frontier with opportunity for novel therapeutic manipulation of ion channels in the treatment of heart disease. Although much research has generally focused on internalization and subsequent degradation of ion channels, the field of forward trafficking of de novo ion channels from the cell interior to the sarcolemma has now emerged as a key regulatory step in cardiac electrophysiological function. In this brief review, we provide an overview of the current understanding of the cellular biology governing the forward trafficking of ion channels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.