ArticleCell metabolism2010
EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity.
Article in Cell metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 55 citations in OpenAlex.
- Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth.Nature communications · 2025Article
- Topoisomerase inhibitor amonafide enhances defense responses to promote longevity in C. elegans.GeroScience · 2025Article
- Human V-ATPase function is positively and negatively regulated by TLDc proteins.Structure (London, England : 1993) · 2024Article
- Yeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase.The EMBO journal · 2024Article
- Targeting of lysosomal-bound protein mEAK-7 for cancer therapy.Frontiers in oncology · 2024Review
- CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7.Life science alliance · 2022Article
- Improving Analysis and Annotation of Microarray Data with Protein Interactions.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Prohibitin depletion extends lifespan of a TORC2/SGK-1 mutant through autophagy and the mitochondrial UPR.Aging cell · 2021Article
- A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response.GeroScience · 2021Article
- Starvation Responses Throughout theGenetics · 2020Review
- Requirement for translocon-associated protein (TRAP) α in insulin biogenesis.Science advances · 2019Article
- Article
- Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.Mechanisms of ageing and development · 2019Review
- Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.Science advances · 2018Article
- Brain-gut communications via distinct neuroendocrine signals bidirectionally regulate longevity inGenes & development · 2018Article
- TLDc proteins: new players in the oxidative stress response and neurological disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Review
- HIF-1-dependent regulation of lifespan inAging · 2017Article
- A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity.Development (Cambridge, England) · 2017Article
- Comprehensive functional genomics using Caenorhabditis elegans as a model organism.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Article
- N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in Vivo.G3 (Bethesda, Md.) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
FoxO transcription factors control development and longevity in diverse species. Although FoxO regulation via changes in its subcellular localization is well established, little is known about how FoxO activity is regulated in the nucleus. Here, we show that the conserved C. elegans protein EAK-7 acts in parallel to the serine/threonine kinase AKT-1 to inhibit the FoxO transcription factor DAF-16. Loss of EAK-7 activity promotes diapause and longevity in a DAF-16/FoxO-dependent manner. Whereas akt-1 mutation activates DAF-16/FoxO by promoting its translocation from the cytoplasm to the nucleus, eak-7 mutation increases nuclear DAF-16/FoxO activity without influencing DAF-16/FoxO subcellular localization. Thus, EAK-7 and AKT-1 inhibit DAF-16/FoxO activity via distinct mechanisms. Our results implicate EAK-7 as a FoxO regulator and highlight the biological impact of a regulatory pathway that governs the activity of nuclear FoxO without altering its subcellular location.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.