ArticleThe Journal of allergy and clinical immunology2010
Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999.
Article in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Association Between Helicobacter pylori Exposure and Decreased Odds of Eosinophilic Esophagitis-A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019Pooled it
- Recommendations for the diagnosis and management of eosinophilic esophagitis in adults and children in Canada: a Delphi consensus project.Journal of the Canadian Association of Gastroenterology · 2025Review
- Recommendations for the diagnosis and management of eosinophilic esophagitis in adults and children in Canada: a Delphi consensus project.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Review
- Endoluminal functional lumen imaging probe: a new modality in the evaluation of esophageal disorders in children and preliminary use in eosinophilic esophagitis.Frontiers in pediatrics · 2025Article
- A unique role for IL-13 in inducing esophageal eosinophilia through MID-1 and STAT6.Frontiers in allergy · 2023Article
- Drivers of Variation in Diagnosis and Management of Eosinophilic Esophagitis: A Survey of Pediatric Gastroenterologists.Digestive diseases and sciences · 2022Article
- Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects.International journal of molecular sciences · 2020Review
- Food Allergy from Infancy Through Adulthood.The journal of allergy and clinical immunology. In practice · 2020Review
- Pharmacotherapies for the Treatment of Eosinophilic Esophagitis: State of the Art Review.Drugs · 2019Review
- Monoclonal Antibodies for Treatment of Eosinophilic Esophagitis.Clinical reviews in allergy & immunology · 2018Review
- Pathophysiology of Eosinophilic Esophagitis.Clinical reviews in allergy & immunology · 2018Review
- Eosinophilic Esophagitis Clinical Manifestations and Differential Diagnosis.Clinical reviews in allergy & immunology · 2018Review
- Epidemiology and Natural History of Eosinophilic Esophagitis.Gastroenterology · 2018Review
- Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2018Article
- Determination of esophageal eosinophil counts and other histologic features of eosinophilic esophagitis by pathology trainees is highly accurate.Human pathology · 2017Article
- Eosinophilic Gastrointestinal Disorders Pathology.Frontiers in medicine · 2017Review
- Mechanisms of Disease of Eosinophilic Esophagitis.Annual review of pathology · 2016Review
- Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis.Gastroenterology · 2016Observational
- Recent discoveries and emerging therapeutics in eosinophilic esophagitis.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundEosinophilic esophagitis (EE) is now a commonly encountered disorder that was rarely diagnosed a decade ago.
objectiveWe aimed to determine the epidemiologic and histologic features of retrospective pediatric esophageal eosinophilia before the first case of EE at our institution was recognized.
methodsEsophageal biopsy specimens obtained between 1982 and 1999 with reflux esophagitis were re-examined and reorganized into 2 groups based on peak esophageal eosinophil number (<15 eosinophils per high-powered field [hpf] and > or =15 eosinophils/hpf). The epidemiology and histology of the entire cohort and a population-based cohort were evaluated.
resultsEight hundred seven biopsy specimens from 666 patients were re-examined; 198 patients had 15 eosinophils/hpf or greater. Among a population-based cohort of patients with 15 eosinophils/hpf or greater, there was a modest increase in incidence (P < .001; incidence rate ratio, 1.18; 95% CI, 1.09-1.28). After correcting for a 40-fold increase in the number of endoscopies during this time period, the proportion of biopsy specimens with 15 eosinophils/hpf or greater did not change (0.08 in 1982 vs 0.08 in 1996 [peak]; P = .9; incidence rate ratio, 1.02; 95% CI, 0.73-1.44). Patients who had as few as 5 eosinophils/hpf were more likely to have persistent esophageal eosinophilia on repeat esophagogastroduodenoscopy, evidence of basal layer hyperplasia, and lamina propria fibrosis compared with patients with less than 5 eosinophils/hpf (P < .001).
conclusionsEsophageal eosinophilia at levels consistent with EE was present among 30% of patients given diagnoses of reflux esophagitis, and the incidence of esophageal eosinophilia did not change over time. Patients with 5 eosinophils/hpf or greater had evidence of other histologic abnormalities and were likely to have persistent esophageal eosinophilia.
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