ArticleJournal of pediatric surgery2010
Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failure.
Article in Journal of pediatric surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Antimicrobial locks for the prevention of central line associated bloodstream infections in pediatric patients: a systematic review and network meta-analysis.Antimicrobial resistance and infection control · 2026Pooled it
- Systematic Review and Meta-Analysis of the Utilization of Ethanol Locks in Pediatric Patients With Intestinal Failure.JPEN. Journal of parenteral and enteral nutrition · 2018Pooled it
- Antibiotic and other lock treatments for tunnelled central venous catheter-related infections in children with cancer.The Cochrane database of systematic reviews · 2013Pooled it
- A randomised controlled trial of Heparin versus EthAnol Lock THerapY for the prevention of Catheter Associated infecTion in Haemodialysis patients--the HEALTHY-CATH trial.BMC nephrology · 2012Trial
- Ethanol Lock for Prevention of CVC-Related Bloodstream Infection in Pediatric Patients: A Systematic Review and Meta-Analysis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Multidisciplinary Management in Pediatric Ultrashort Bowel Syndrome.Journal of multidisciplinary healthcare · 2020Review
- Diagnosis and management of catheter-related bloodstream infections in patients on home parenteral nutrition.Frontline gastroenterology · 2020Review
- Comparison of the effect of antibiotic-lock and ethanol-lock methods on infection rate in children with hemodialysis catheter.American journal of clinical and experimental urology · 2019Article
- Hidden morbidity of ethanol lock therapy.Pediatric surgery international · 2018Article
- Ethanol Lock Efficacy and Associated Complications in Children With Intestinal Failure.JPEN. Journal of parenteral and enteral nutrition · 2016Article
- Neurodevelopmental and Cognitive Outcomes in Children With Intestinal Failure.Journal of pediatric gastroenterology and nutrition · 2016Article
- The relationship between hand hygiene and health care-associated infection: it's complicated.Infection and drug resistance · 2015Review
- Short bowel syndrome in the NICU.Clinics in perinatology · 2013Review
- Characterization of post-hospital infections in adults requiring home parenteral nutrition.Nutrition (Burbank, Los Angeles County, Calif.) · 2013Article
- Full and broad-spectrum in vivo eradication of catheter-associated biofilms using gentamicin-EDTA antibiotic lock therapy.Antimicrobial agents and chemotherapy · 2012Article
- Prevention and treatment of intestinal failure-associated liver disease in children.Seminars in liver disease · 2012Article
- Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium.The Journal of pediatrics · 2012Article
- Central venous catheter repair is associated with an increased risk of bacteremia and central line-associated bloodstream infection in pediatric patients.The Pediatric infectious disease journal · 2012Article
- Infection in pediatric interventional radiology.Pediatric radiology · 2011Review
- A comparison of catheter lock solutions and associated complications in pediatric intestinal failure patients.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeWe sought to determine whether a regimen of 70% ethanol locks could reduce the rate of central venous catheter (CVC) infections in parenteral nutrition-dependent children with intestinal failure.
methodsWe performed a retrospective review of 23 parenteral nutrition-dependent children in our multidisciplinary intestinal rehabilitation clinic who started ethanol lock therapy between September 2007 and June 2009. The treatment regimen consisted of a 70% ethanol lock instilled 3 times per week in each catheter lumen. The rate of CVC infections before and after initiation of ethanol lock therapy was compared using the Wilcoxon signed ranks test with significance set at P < .05.
resultsThe most common diagnoses leading to intestinal failure were necrotizing enterocolitis (26.1%), gastroschisis (21.7%), and intestinal atresia (14.3%). Ethanol locks were well tolerated with no reported adverse side effects. The infection rate decreased from 9.9 per 1000 catheter days prior to initiation of ethanol locks to 2.1 per 1000 catheter days during therapy (P = .03).
conclusionsA regimen of ethanol lock therapy administered three days per week appears to be a safe and effective means of reducing the rate of CVC infections in parenteral nutrition-dependent children with intestinal failure.
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