ArticleMetabolism: clinical and experimental2010
Systemic inflammation and the metabolic syndrome among middle-aged community volunteers.
Article in Metabolism: clinical and experimental, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis.Frontiers in immunology · 2024Pooled it
- Effects of Oats (Frontiers in nutrition · 2021Pooled it
- Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance.Metabolism: clinical and experimental · 2012Pooled it
- Association of angiotensin-converting enzyme gene I/D polymorphism with chronic obstructive pulmonary disease: a meta-analysis.Journal of the renin-angiotensin-aldosterone system : JRAASPooled it
- Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial.Scientific reports · 2021Trial
- Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores.Neurology · 2017Trial
- Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome.Nutrition research (New York, N.Y.) · 2011Trial
- Childhood socioeconomic status and changes in biological aging across mid-to-later life.Social science & medicine (1982) · 2026Article
- Trajectories of depressive symptoms across pregnancy and the extended postpartum period and future cardiovascular health.medRxiv : the preprint server for health sciences · 2026Article
- Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies.Military Medical Research · 2026Article
- Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- The association between inflammatory markers, walking speed, and metabolic syndrome in older Chinese adults.Aging clinical and experimental research · 2025Article
- Neighborhood disorder and social cohesion: A longitudinal investigation of links with maternal cardiometabolic risk one year postpartum.Journal of psychosomatic research · 2025Article
- Prospective analysis of metabolic syndrome and inflammation in aortic aneurysm risk: UK Biobank study.Frontiers in endocrinology · 2025Article
- Sex-specific associations between childhood trauma and adult systemic inflammation in daily life.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Understanding the Etiopathogenesis of Non-Arteritic Anterior Ischemic Optic Neuropathy with Laboratory Findings.Beyoglu eye journal · 2024Article
- The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms.Frontiers in pharmacology · 2024Review
- Inflammatory biomarkers link perceived stress with metabolic dysregulation.Brain, behavior, & immunity - health · 2023Article
- Subjective Social Status and Longitudinal Changes in Systemic Inflammation.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The metabolic syndrome is conceptualized as a clustering of risk factors--including insulin resistance, dyslipidemia, central adiposity, and elevated blood pressure (BP)--that increase the risk for cardiovascular disease and type 2 diabetes mellitus. Recent evidence suggests that markers of systemic inflammation may be included in the definition of the syndrome and play some role in its pathogenesis. In this study, we use a statistical modeling technique, confirmatory factor analysis, to evaluate relationships of systemic inflammation, as measured by plasma concentrations of C-reactive protein and interleukin-6, with the component factors of the metabolic syndrome (insulin resistance, dyslipidemia, central adiposity, and elevated BP) and to examine whether inflammation is a potential common pathway linking established components to the full syndrome. Subjects were 645 community volunteers aged 30 to 54 years (48% male, 82% European American, 18% African American). Consistent with existing literature, structural equation modeling adjusting for age, sex, and race confirmed a higher-order common factor underlying the covariation of insulin resistance, dyslipidemia, adiposity, and BP. Inflammation was positively associated with this common factor, accounting for 54% of its variance and partially mediating statistical aggregation of the component factors comprising the metabolic syndrome. These results were particularly strong for adiposity, raising the possibility that inflammatory processes stimulated by intraabdominal adipose tissue contribute to the development of the metabolic syndrome. The inclusion of inflammatory markers in the clinical definition of metabolic syndrome seems warranted and may improve prognostic assessment of risk of type 2 diabetes mellitus and cardiovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.