ArticleBMC cancer2010
Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Assessment of Antioxidant Enzyme Superoxide Dismutase (SOD) in Oral Cancer: Systematic Review and Meta-Analysis.Disease markers · 2024Pooled it
- Association of reduced XRCC2 expression with lymph node metastasis in breast cancer tissues.Familial cancer · 2014Pooled it
- SOD2-Superoxide Metabolic Axis Regulates Mitophagy and Modulates TKIs Sensitivity in Head and Neck Squamous Cell Carcinoma.Cancer science · 2026Article
- Antioxidant Enzymes in Cancer Cells: Their Role in Photodynamic Therapy Resistance and Potential as Targets for Improved Treatment Outcomes.International journal of molecular sciences · 2024Review
- Interaction between Cigarette Smoke and Human Papillomavirus 16 E6/E7 Oncoproteins to Induce SOD2 Expression and DNA Damage in Head and Neck Cancer.International journal of molecular sciences · 2023Article
- Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling.Frontiers in public health · 2021Article
- Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.Oncotarget · 2018Article
- High glucose enhances the metastatic potential of tongue squamous cell carcinoma via the PKM2 pathway.Oncotarget · 2017Article
- Pyruvate kinase M2 deregulation enhances the metastatic potential of tongue squamous cell carcinoma.Oncotarget · 2017Article
- Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway.Oncotarget · 2017Article
- SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma.Scientific reports · 2016Article
- Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.Antioxidants & redox signaling · 2015Article
- SOD2 immunoexpression predicts lymph node metastasis in penile cancer.BMC clinical pathology · 2015Article
- Bmi1 drives stem-like properties and is associated with migration, invasion, and poor prognosis in tongue squamous cell carcinoma.International journal of biological sciences · 2015Article
- Identification of biomarkers for lymph node metastasis in early-stage cervical cancer by tissue-based proteomics.British journal of cancer · 2014Article
- Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses.BMC cancer · 2013Article
- Mitochondrial proteomics of nasopharyngeal carcinoma metastasis.BMC medical genomics · 2012Article
- Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.Free radical biology & medicine · 2012Article
- Deregulation of Snai2 is associated with metastasis and poor prognosis in tongue squamous cell carcinoma.International journal of cancer · 2012Article
- Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma.Molecular oncology · 2012Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundLymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic information to facilitate clinical decision making. Previous studies showed that deregulation of manganese superoxide dismutase (SOD2) expression is a frequent event in TSCC and may be associated with enhanced cell invasion. The purpose of this study is to further evaluate whether the expression level of SOD2 is correlated with the metastatic status in TSCC patients.
methodsWe first examined the SOD2 expression at mRNA level on 53 TSCC and 22 normal control samples based on pooled-analysis of existing microarray datasets. To confirm our observations, we examined the expression of SOD2 at protein level on an additional TSCC patient cohort (n = 100), as well as 31 premalignant dysplasias, 15 normal tongue mucosa, and 32 lymph node metastatic diseases by immunohistochemistry (IHC).
resultsThe SOD2 mRNA level in primary TSCC tissue is reversely correlated with lymph node metastasis in the first TSCC patient cohort. The SOD2 protein level in primary TSCC tissue is also reversely correlated with lymph node metastasis in the second TSCC patient cohort. Deregulation of SOD2 expression is a common event in TSCC and appears to be associated with disease progression. Statistical analysis revealed that the reduced SOD2 expression in primary tumor tissue is associated with lymph node metastasis in both TSCC patient cohorts examined.
conclusionsOur study suggested that the deregulation of SOD2 in TSCC has potential predictive values for lymph node metastasis, and may serve as a therapeutic target for patients at risk of metastasis.
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