ArticleMolecular plant pathology2010
FgTep1p is linked to the phosphatidylinositol-3 kinase signalling pathway and plays a role in the virulence of Fusarium graminearum on wheat.
Article in Molecular plant pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Transcriptome Analysis Reveals the Function of a G-Protein α Subunit Gene in the Growth and Development ofJournal of fungi (Basel, Switzerland) · 2023Article
- Alternative Splicing ofFrontiers in microbiology · 2021Article
- Involvement of the Mitochondrial Protein Tyrosine Phosphatase PTPM1 in the Promotion of Conidiation, Development, and Pathogenicity inFrontiers in microbiology · 2020Article
- Deletion ofJournal of fungi (Basel, Switzerland) · 2018Article
- On the trail of a cereal killer: recent advances in Fusarium graminearum pathogenomics and host resistance.Molecular plant pathology · 2012Review
- A conserved homeobox transcription factor Htf1 is required for phialide development and conidiogenesis in Fusarium species.PloS one · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Both mammalian tensin-like phosphatase 1 [TEP1; also known as phosphatase deleted on chromosome 10 (PTEN) or mutated in multiple advanced cancer 1 (MMAC1)] and Saccharomyces cerevisiae ScTep1p are involved in the phosphatidylinositol pathway. In this study, we identified the Fusarium graminearum locus FGSG_04982.3 (named FgTEP1) as the functional homologue of ScTEP1 in the sensitivity of S. cerevisiae cells to wortmannin, the phosphatidylinositol-3 kinase inhibitor. Deletion of FgTEP1 causes F. graminearum mycelial growth to become sensitive to lithium and reduces the production of conidia. Although conidia lacking FgTEP1 germinate normally, they show reduced germination efficiency in the presence of wortmannin. In addition, we showed that deletion of FgTEP1 reduces the virulence of F. graminearum on wheat. These results indicate that FgTep1p is linked to the phosphatidylinositol-3 kinase signalling pathway in this plant fungal pathogen.
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