ReviewMicrocirculation (New York, N.Y. : 1994)2010
Endothelium-dependent control of vascular tone during early postnatal and juvenile growth.
Review in Microcirculation (New York, N.Y. : 1994), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Fetal Cerebral Blood Flow (Dys)autoregulation.Diagnostics (Basel, Switzerland) · 2025Review
- Perinatal hypoxia weakens anticontractile influence of NO in rat arteries during early postnatal period.Pediatric research · 2024Article
- Significance of Pulmonary Endothelial Injury and the Role of Cyclooxygenase-2 and Prostanoid Signaling.Bioengineering (Basel, Switzerland) · 2023Review
- Application of coagulation parameters at the time of necrotizing enterocolitis diagnosis in surgical intervention and prognosis.BMC pediatrics · 2022Article
- The role of gasotransmitters in neonatal physiology.Nitric oxide : biology and chemistry · 2020Review
- Maturation of Intestinal Oxygenation: A Review of Mechanisms and Clinical Implications for Preterm Neonates.Frontiers in pediatrics · 2020Review
- In Development-A New Paradigm for Understanding Vascular Disease.Journal of cardiovascular pharmacology · 2017Review
- Cutaneous control of blood pressure.Current opinion in nephrology and hypertension · 2016Review
- Biomarker correlates of survival in pediatric patients with Ebola virus disease.Emerging infectious diseases · 2014Article
- Early developmental conditioning of later health and disease: physiology or pathophysiology?Physiological reviews · 2014Review
- Neural programming of mesenteric and renal arteries.American journal of physiology. Heart and circulatory physiology · 2014Article
- The atypical structure and function of newborn arterial endothelium is mediated by Rho/Rho kinase signaling.American journal of physiology. Heart and circulatory physiology · 2014Article
- HIF isoforms in the skin differentially regulate systemic arterial pressure.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Pressure-induced maturation of endothelial cells on newborn mouse carotid arteries.American journal of physiology. Heart and circulatory physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Endothelial dysfunction can develop at an early age in children with risk factors for cardiovascular disease. A clear understanding of the nature of this dysfunction and how it can worsen over time requires detailed information on the normal growth-related changes in endothelial function on which the pathological changes are superimposed. This review summarizes our current understanding of these normal changes, as derived from studies in four different mammalian species. Although the endothelium plays an important role in controlling vascular tone from birth onward, the vasoactive molecules that mediate this control often change during postnatal or juvenile growth. The specifics of this transition to an adult endothelial cell phenotype can vary depending on the vascular bed. During growth, the contribution of nitric oxide to endothelium-dependent dilation generally increases in the lung, cerebral cortex, and skeletal muscle, but decreases in the intestine. Endothelial capacity for release of other vasoactive factors (e.g., cyclooxygenase products, hydrogen peroxide, carbon monoxide) can also increase or decrease during growth. Although these changes have been well documented, there is less information on their underlying cellular or molecular events. Further research is required to clarify these mechanisms, and to evaluate the functional significance of such shifts in endothelial phenotype.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.