ArticleJournal of medical primatology2010
Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeys.
Article in Journal of medical primatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Unconventional T cells in brain homeostasis, injury and neurodegeneration.Frontiers in immunology · 2023Review
- Conservation of molecular and cellular phenotypes of invariant NKT cells between humans and non-human primates.Immunogenetics · 2019Article
- Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment.Retrovirology · 2015Article
- Balance of CD8+ CD28+ / CD8+ CD28- T lymphocytes is vital for patients with ulcerative colitis.Digestive diseases and sciences · 2013Article
- Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection.PLoS pathogens · 2013Article
- Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection.PLoS pathogens · 2012Article
- Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.Current opinion in HIV and AIDS · 2012Review
- Article
- CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.Journal of virology · 2011Article
- SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase.Microbes and infection · 2011Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundWe have recently reported the presence of CD8(+) and CD4/8 double-negative (DN) natural killer T (NKT) lymphocytes in sooty mangabeys. To investigate differences in the two NKT cell subsets, we compared the phenotype and function of sooty mangabey CD8(+) and DN NKT cells.
methodsFlow-sorted NKT lymphocytes from one SIV-negative sooty mangabey were subjected to limiting dilution cloning. Invariant NKT clones were characterized by flow cytometry and cytokine ELISA.
resultsThe majority of NKT clones displayed an effector memory phenotype and expressed CXCR3 and NKG2D. While CD8(+) NKT subsets expressed significantly higher levels of granzyme B and perforin and produced more IFN-gamma, the DN NKT subsets secreted significantly more IL-4, IL-13, and IL-10.
conclusionsThe Th1 and Th2 cytokine bias of CD8(+) and DN NKT cells, respectively, indicates the presence of functionally heterogeneous populations of NKT cells in sooty mangabeys.
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Registered trials
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