ReviewJournal of medical primatology2010
Primate-specific regulation of natural killer cells.
Review in Journal of medical primatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 70 citations in OpenAlex.
- Effect of short-term oral prednisone therapy on blood gene expression: a randomised controlled clinical trial.Respiratory research · 2019Trial
- Taxonomic variation in immune response strategies among primates.Genes and immunity · 2025Review
- MHC Class I Ligands of Rhesus Macaque Killer Cell Ig-like Receptors.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.Frontiers in genetics · 2022Review
- The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity.Cells · 2021Review
- Article
- Differences in MHC-B diversity and KIR epitopes in two populations of wild chimpanzees.Immunogenetics · 2019Article
- Unraveling the LRC Evolution in Mammals: IGSF1 and A1BG Provide the Keys.Genome biology and evolution · 2019Article
- KIR gene presence/absence polymorphisms and global diversity in the Kirgiz ethnic minority and populations distributed worldwide.Molecular biology reports · 2019Article
- Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees.BMC evolutionary biology · 2019Article
- Monkeying Around: Using Non-human Primate Models to Study NK Cell Biology in HIV Infections.Frontiers in immunology · 2019Review
- Diversification of Bw4 Specificity and Recognition of a Nonclassical MHC Class I Molecule Implicated in Maternal-Fetal Tolerance by Killer Cell Ig-like Receptors of the Rhesus Macaque.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Comparative immunity of antigen recognition, differentiation, and other functional molecules: similarities and differences among common marmosets, humans, and mice.Experimental animals · 2018Review
- Missing or altered self: human NK cell receptors that recognize HLA-C.Immunogenetics · 2017Review
- Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?Frontiers in immunology · 2017Review
- GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.Stem cell reports · 2016Article
- FRAMA: from RNA-seq data to annotated mRNA assemblies.BMC genomics · 2016Article
- Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The killer-cell immunoglobulin-like receptors of macaques.Immunological reviews · 2015Review
- A Coevolutionary Arms Race between Hosts and Viruses Drives Polymorphism and Polygenicity of NK Cell Receptors.Molecular biology and evolution · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Natural killer (NK) cells are circulating lymphocytes that function in innate immunity and placental reproduction. Regulating both development and function of NK cells is an array of variable and conserved receptors that interact with major histocompatibility complex (MHC) class I molecules. Families of lectin-like and immunoglobulin-like receptors are determined by genes in the natural killer complex (NKC) and leukocyte receptor complex (LRC), respectively. As a consequence of the strong, varying pressures on the immune and reproductive systems, NK cell receptors and their MHC class I ligands evolve rapidly, are highly diverse and exhibit dramatic species-specific differences. The variable, polymorphic family of killer cell immunoglobulin-like receptors (KIR) that regulate human NK cell development and function arose recently, from a single-copy gene during the evolution of simian primates. Our studies of KIR and MHC class I genes in representative species show how these two unlinked but functionally intertwined genetic complexes have co-evolved. In humans, combinations of KIR and HLA class I factors are associated with infectious diseases, including HIV/AIDS, autoimmunity, reproductive success and the outcome of therapeutic transplantation. The extraordinary, and unanticipated, divergence of human NK cell receptors and MHC class I ligands from their mouse counterparts can in part explain the difficulties experienced in finding informative mouse models for human diseases. Non-human primate models have far greater potential, but to realize their promise will first require more complete definition of the genetics and function of KIR and MHC variation in non-human primate species, at a level comparable to that achieved for the human species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.