ReviewEpilepsia2010
Modeling new therapies for infantile spasms.
Review in Epilepsia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- The multiple hit model of infantile and epileptic spasms: The 2025 update.Epilepsia open · 2025Article
- The response patterns of infantile spasms to treatments in 156 patients: Hormonal therapy with intravenous synthetic ACTH appears promising.Neurosciences (Riyadh, Saudi Arabia) · 2022Article
- Genetic variations associated with pharmacoresistant epilepsy (Review).Molecular medicine reports · 2020Review
- Article
- Inflammation in Epileptic Encephalopathies.Advances in protein chemistry and structural biology · 2017Review
- Improving Outcomes in Infantile Spasms: Role of Pharmacotherapy.Paediatric drugs · 2016Review
- Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms.Epilepsy research · 2014Article
- Issues for new antiepilepsy drug development.Current opinion in neurology · 2013Review
- Latest American and European updates on infantile spasms.Current neurology and neuroscience reports · 2013Review
- Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms.Current opinion in neurobiology · 2012Review
- Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target.Epilepsia · 2012Review
- The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.Journal of medicinal chemistry · 2012Article
- Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms.Epilepsia · 2011Article
- A pulse rapamycin therapy for infantile spasms and associated cognitive decline.Neurobiology of disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Infantile spasms are the classical seizure type of West syndrome. Infantile spasms often herald a dismal prognosis, due to the high probability to evolve into intractable forms of epilepsies with significant cognitive deficits, especially if not adequately treated. The current therapies-high doses of adrenocorticotropic hormone, steroids, or the gamma-aminobutyric acid (GABA) transaminase inhibitor vigabatrin--are often toxic and may not always be effective. The need to identify new therapies for spasms has led to the generation of a number of rodent models of infantile spasms. These include acute and chronic models of infantile spasms, with cryptogenic or symptomatic origin, many of which are based on specific etiologies. In this review, we summarize the clinical experience with treating infantile spasms and the main features of the new animal models of infantile spasms and discuss their utility in the preclinical development of new therapies for infantile spasms.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.