ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2010
CD14, a key candidate gene associated with a specific immune response to cockroach.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Environmental assessment and exposure reduction of cockroaches: a practice parameter.The Journal of allergy and clinical immunology · 2013Guideline
- Reciprocal expression of the immune response genes CXCR3 and IFI44L as module hubs are associated with patient survivals in primary central nervous system lymphoma.International journal of clinical oncology · 2023Article
- Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.The Journal of allergy and clinical immunology · 2018Article
- New Insights into Cockroach Allergens.Current allergy and asthma reports · 2017Review
- Aryl hydrocarbon receptor (AhR) modulates cockroach allergen-induced immune responses through active TGFβ1 release.Mediators of inflammation · 2014Article
- Functional interaction of cockroach allergens and mannose receptor (CD206) in human circulating fibrocytes.PloS one · 2013Article
- Role of cockroach proteases in allergic disease.Current allergy and asthma reports · 2012Review
- Sensitization to cockroach allergen: immune regulation and genetic determinants.Clinical & developmental immunology · 2012Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSensitization to cockroach allergen is one of the strongest predictors of asthma morbidity, especially among African Americans.
objectiveOur aims were to determine the genomic basis of cockroach sensitization and the specific response to cockroach antigen.
methodsWe investigated the Th1/Th2 cytokine profile of co-cultured plasmacytoid dendritic cells (pDCs) and CD4+ T cells and the 'transcript signature' of the immune response to cockroach antigen using high-throughput expression profiling of co-cultured cells.
resultsWe observed significantly elevated levels of IL-13, IL-10, and TNF-alpha, but undetectable levels of IL-12p70 and IFN-alpha, when cultures were exposed to crude cockroach antigen. A significant difference was observed for IL-13 between cockroach-allergic and non-allergic individuals (P=0.039). Microarray analyses demonstrated a greater response at 48 h compared with 4 h, with 50 genes being uniquely expressed in cockroach antigen-treated cells, including CD14, S100A8, CCL8, and IFI44L. The increased CD14 expression was further observed in purified pDCs, human monocytic THP-1 cells, and the supernatant of co-cultured pDCs and CD4+ T cells on exposure to cockroach extract. Furthermore, the most differential expression of CD14 between cockroach allergy and non-cockroach allergy was only observed among individuals with the CC 'high-risk' genotype of the CD14-260C/T. Ingenuity Pathways Analysis analyses suggested the IFN signalling as the most significant canonical pathway.
conclusionOur results suggest that these differentially expressed genes, particularly CD14, and genes in the IFN signalling pathway may be important candidates for further investigation of their role in the immune response to cockroach allergen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.