ArticleThe Journal of infectious diseases2010
Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000168 (Studies of Ocular Complications of AIDS), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies of Ocular Complications of AIDS (SOCA)
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection.Communications biology · 2021Pooled it
- Clinical, molecular, and immunologic mechanisms of CMV retinitis: Evolving understanding in HIV and non-HIV immunosuppressed patients.Expert review of ophthalmology · 2025Article
- CMV Retinitis in the Context of SARS-CoV-2 Infection: A Case Study and Comprehensive Review of Viral Interactions.Pathogens (Basel, Switzerland) · 2024Review
- Intrauterine Viral Infections: Impact of Inflammation on Fetal Neurodevelopment.Frontiers in neuroscience · 2021Review
- Long-term prophylaxis in an immunocompetent patient with Cytomegalovirus retinitis: a case report and review of literature.Journal of ophthalmic inflammation and infection · 2020Article
- Genetic variation in toll like receptors 2, 7, 9 and interleukin-6 is associated with cytomegalovirus infection in late pregnancy.BMC medical genetics · 2020Article
- Cytomegalovirus Retinitis in HIV and Non-HIV Individuals.Microorganisms · 2019Review
- Relationship Between Opacity of Cytomegalovirus Retinitis Lesion Borders and Severity of Immunodeficiency Among People With AIDS.Investigative ophthalmology & visual science · 2019Observational
- Cytokine-Mediated Induction and Regulation of Tissue Damage During Cytomegalovirus Infection.Frontiers in immunology · 2019Review
- Host Genetics of Cytomegalovirus Pathogenesis.Frontiers in genetics · 2019Review
- Cytomegalovirus retinitis in the post-cART era.Current ophthalmology reports · 2018Article
- Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Modulation of the Host Environment by Human Cytomegalovirus with Viral Interleukin 10 in Peripheral Blood.The Journal of infectious diseases · 2017Article
- Humoral immunity to cytomegalovirus and chronic graft-versus-host disease.Viral immunology · 2012Article
- Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response.Genes and immunity · 2012Article
- Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus.American journal of ophthalmology · 2011Article
- Cytomegalovirus retinitis and the acquired immunodeficiency syndrome--bench to bedside: LXVII Edward Jackson Memorial Lecture.American journal of ophthalmology · 2011Article
- An unusual case of presumed cytomegalovirus: retinitis in a non-HIV patient treated for IgG 4-related disease.Arquivos brasileiros de oftalmologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.
methodsEffects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284).
resultsIn European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed.
conclusionHost genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.