ArticleJournal of molecular neuroscience : MN2011
Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors.
Article in Journal of molecular neuroscience : MN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?Journal of neurodevelopmental disorders · 2019Review
- Purinergic signalling during development and ageing.Purinergic signalling · 2015Review
- Effects of ATP and NGF on Proliferation and Migration of Neural Precursor Cells.Neurochemical research · 2015Article
- Degradation of intestinal mRNA: a matter of treatment.World journal of gastroenterology · 2015Article
- P2X receptors in maintenance and differentiation of neural progenitor cells.Neural regeneration research · 2014Article
- Heteromeric assembly of P2X subunits.Frontiers in cellular neuroscience · 2013Review
- Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems.Purinergic signalling · 2013Article
- Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation.Cell communication and signaling : CCS · 2013Article
- Kinin-B2 receptor activity determines the differentiation fate of neural stem cells.The Journal of biological chemistry · 2012Article
- Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair.Stem cell reviews and reports · 2012Review
- Interactions between the NO-citrulline cycle and brain-derived neurotrophic factor in differentiation of neural stem cells.The Journal of biological chemistry · 2012Article
- ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors.The Journal of biological chemistry · 2012Article
- Purinergic signaling in embryonic and stem cell development.Cellular and molecular life sciences : CMLS · 2011Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Neural differentiation has been extensively studied in vitro in a model termed neurospheres, which consists of aggregates of neural progenitor cells. Previous studies suggest that they have a great potential for the treatment of neurological disorders. One of the major challenges for scientists is to control cell fate and develop ideal culture conditions for neurosphere expansion in vitro, without altering their features. Similar to human neural progenitors, rat neurospheres cultured in the absence of epidermal and fibroblast growth factors for a short period increased the levels of β-3 tubulin and decreased the expression of glial fibrillary acidic protein and nestin, compared to neurospheres cultured in the presence of these factors. In this work, we show that rat neurospheres cultured in suspension under mitogen-free condition presented significant higher expression of P2X2 and P2X6 receptor subunits, when compared to cells cultured in the presence of growth factors, suggesting a direct relationship between P2X2/6 receptor expression and induction of neuronal differentiation in mitogen-free cultured rat neurospheres.
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