ArticleJournal of biomedicine & biotechnology2010
Expression of nestin, vimentin, and NCAM by renal interstitial cells after ischemic tubular injury.
Article in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Vimentin Targeted Nano-gene Carrier for Treatment of Renal Diseases.Journal of Korean medical science · 2021Article
- Early Renoprotective Effect of Ruxolitinib in a Rat Model of Diabetic Nephropathy.Pharmaceuticals (Basel, Switzerland) · 2021Article
- L-carnitine suppresses cisplatin-induced renal injury in rats: impact on cytoskeleton proteins expression.Toxicology research · 2021Article
- Argan oil ameliorates sodium fluoride-induced renal damage via inhibiting oxidative damage, inflammation, and intermediate filament protein expression in male rats.Environmental science and pollution research international · 2020Article
- Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the "kidney governing bone" theory.Journal of orthopaedic surgery and research · 2020Article
- Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells.PloS one · 2018Article
- Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.PloS one · 2015Article
- Intratracheal Bleomycin Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis Rat Model?BioMed research international · 2015Article
- Nestin expression in mesenchymal stromal cells: regulation by hypoxia and osteogenesis.BMC veterinary research · 2014Article
- Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation.PloS one · 2014Article
- Role of anti-vimentin antibodies in allograft rejection.Human immunology · 2013Review
- Pancreatic cancer with Nest-in tendencies.Cancer biology & therapy · 2011Article
- Bone Marrow Mononuclear Cells Restore Normal Mitochondrial CaCell transplantationArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work explores the distribution of various markers expressed by interstitial cells in rat kidneys after ischemic injury (35 minutes) during regeneration of S3 tubules of outer stripe of outer medulla (OSOM). Groups of experimental animals (n = 4) were sacrificed every two hours during the first 24 hours post-ischemia as well as 2, 3, 7, 14 days post-ischemia. The occurrence of lineage markers was analyzed on kidney sections by immunohistochemistry and morphometry during the process of tubular regeneration. In postischemic kidneys, interstitial cell proliferation, assessed by 5-bromo-2'-deoxyuridine (BrdU) and Proliferating Cell Nuclear Antigen (PCNA) labeling, was prominent in outer medulla and reach a maximum between 24 and 72 hours after reperfusion. This population was characterized by the coexpression of vimentin and nestin. The density of -Neural Cell Adhesion Molecule (NCAM) positive interstitial cells increased transiently (18-72 hours) in the vicinity of altered tubules. We have also localized a small population of alpha-Smooth Muscle Actin (SMA)-positive cells confined to chronically altered areas and characterized by a small proliferative index. In conclusion, we observed in the postischemic kidney a marked proliferation of interstitial cells that underwent transient phenotypical modifications. These interstitial cells could be implicated in processes leading to renal fibrosis.
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