ArticleInternational journal of environmental research and public health2010
Human amebiasis: breaking the paradigm?
Article in International journal of environmental research and public health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 97 citations in OpenAlex.
- Evaluation of intestinal immune responses to Entamoeba dispar using the first domestic clinical isolate in Japan.PLoS neglected tropical diseases · 2026Article
- Emerging genetic diversity and molecular epidemiology of Entamoeba moshkovskii among patients with acute diarrhoea in Northern India.Tropical medicine and health · 2026Article
- Unusual Case of Hepatic Amebiasis Without Recent Endemic Exposure: A Diagnostic Puzzle.Cureus · 2025Article
- Work with me here: variations in genome content and emerging genetic tools in Entamoeba histolytica.Trends in parasitology · 2025Review
- An Imported Case of Gigantic Amoebic Liver Abscess in a 24-Year-Old Woman in Singapore.Case reports in infectious diseases · 2025Article
- Amoebic Liver Abscesses in Returning Travelers: Lessons to Keep in Mind From a Nonendemic Area.Case reports in infectious diseases · 2025Article
- SymptomaticOpen forum infectious diseases · 2024Article
- Extracellular Cysteine Proteases of Key Intestinal Protozoan Pathogens-Factors Linked to Virulence and Pathogenicity.International journal of molecular sciences · 2023Review
- Amoebiasis: Advances in Diagnosis, Treatment, Immunology Features and the Interaction with the Intestinal Ecosystem.International journal of molecular sciences · 2023Review
- Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Frequency ofJournal of parasitology research · 2023Article
- Prevalence of Human IntestinalPathogens (Basel, Switzerland) · 2022Review
- The Epidemiology ofMedicina (Kaunas, Lithuania) · 2022Article
- Prevalence of Giardiasis and Entamoeba Species in Two of the Six Governorates of Kuwait.Journal of parasitology research · 2022Article
- Prevalence and risk factors of intestinal protozoan infection among symptomatic and asymptomatic populations in rural and urban areas of southern Algeria.BMC infectious diseases · 2021Article
- Article
- Foodborne Parasitic Diseases in the Neotropics - A Review.Helminthologia · 2021Article
- Epidemiology, species composition and genetic diversity of tetra- and octonucleated Entamoeba spp. in different Brazilian biomes.Parasites & vectors · 2021Article
- Evaluation of the PEJournal of immunology research · 2021Article
- Protein Phosphatase PP2C Identification inBioMed research international · 2021Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For over 30 years it has been established that the Entamoeba histolytica protozoan included two biologically and genetically different species, one with a pathogenic phenotype called E. histolytica and the other with a non-pathogenic phenotype called Entamoeba dispar. Both of these amoebae species can infect humans. E. histolytica has been considered as a potential pathogen that can cause serious damage to the large intestine (colitis, dysentery) and other extraintestinal organs, mainly the liver (amebic liver abscess), whereas E. dispar is a species that interacts with humans in a commensal relationship, causing no symptoms or any tissue damage. This paradigm, however, should be reconsidered or re-evaluated. In the present work, we report the detection and genotyping of E. dispar sequences of DNA obtained from patients with amebic liver abscesses, including the genotyping of an isolate obtained from a Brazilian patient with a clinical diagnosis of intestinal amebiasis that was previously characterized as an E. dispar species. The genetic diversity and phylogenetic analysis performed by our group has shown the existence of several different genotypes of E. dispar that can be associated to, or be potentiality responsible for intestinal or liver tissue damage, similar to that observed with E. histolytica.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.