Evidence map›Paper›PMID 20617011›Full record

ArticleInternational journal of environmental research and public health2010

Mechanisms of geomagnetic field influence on gene expression using influenza as a model system: basics of physical epidemiology.

Valeriy Zaporozhan, Andriy Ponomarenko

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 60 citations in OpenAlex.

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  9. Review
  10. Systemic lupus Erythematosus and geomagnetic disturbances: a time series analysis.Environmental health : a global access science source · 2021
    Article
  11. Article
  12. Advances in Residential Design Related to the Influence of Geomagnetism.International journal of environmental research and public health · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Valeriy ZaporozhanOdessa State Medical University, Valekhovsky lane 2, Odessa, Ukraine. rector@odmu.edu.ua
Andriy Ponomarenko
Odessa National Medical University · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies demonstrate distinct changes in gene expression in cells exposed to a weak magnetic field (MF). Mechanisms of this phenomenon are not understood yet. We propose that proteins of the Cryptochrome family (CRY) are "epigenetic sensors" of the MF fluctuations, i.e., magnetic field-sensitive part of the epigenetic controlling mechanism. It was shown that CRY represses activity of the major circadian transcriptional complex CLOCK/BMAL1. At the same time, function of CRY, is apparently highly responsive to weak MF because of radical pairs that periodically arise in the functionally active site of CRY and mediate the radical pair mechanism of magnetoreception. It is known that the circadian complex influences function of every organ and tissue, including modulation of both NF-kappaB- and glucocorticoids- dependent signaling pathways. Thus, MFs and solar cycles-dependent geomagnetic field fluctuations are capable of altering expression of genes related to function of NF-kappaB, hormones and other biological regulators. Notably, NF-kappaB, along with its significant role in immune response, also participates in differential regulation of influenza virus RNA synthesis. Presented data suggests that in the case of global application (example-geomagnetic field), MF-mediated regulation may have epidemiological and other consequences.

Indexed as

Epidemiologic StudiesGene ExpressionMagneticsHumansInfluenza, Humancircadian transcriptionCryptochromeelectromagnetic fieldsepidemiologygene expressionNF-kB, influenzapair radical reactionsSolar cycles

Identifiers

PMID20617011
PMCPMC2872305
OpenAlexW2080595462

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.