ArticleJournal of hypertension2010
Amplification of the association between birthweight and blood pressure with age: the Bogalusa Heart Study.
Article in Journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bogalusa Heart Study
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Allostatic Load in Children and Adolescents: A Systematic Review.Psychotherapy and psychosomatics · 2023Pooled it
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- Breastfeeding in infancy and cardiovascular disease in middle-aged and older adulthood: a prospective study of 0.36 million UK Biobank participants.The journal of nutrition, health & aging · 2024Article
- Maternal smoking during pregnancy links to childhood blood pressure through birth weight and body mass index: NHANES 1999-2018.Journal of human hypertension · 2024Article
- Cardiovascular health profiles in adolescents being born term or preterm-results from the EVA-Tyrol study.BMC cardiovascular disorders · 2023Article
- Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats.Scientific reports · 2023Article
- Antenatal Programming of Hypertension: Paradigms, Paradoxes, and How We Move Forward.Current hypertension reports · 2022Review
- Lifetime cardiovascular risk factors and maternal and offspring birth outcomes: Bogalusa Babies.PloS one · 2022Article
- Birth Weight and Adult Obesity Index in Relation to the Risk of Hypertension: A Prospective Cohort Study in the UK Biobank.Frontiers in cardiovascular medicine · 2021Article
- Early Determinants of Childhood Blood Pressure at the Age of 6 Years: The GECKO Drenthe and ABCD Study Birth Cohorts.Journal of the American Heart Association · 2020Article
- Association between High-Sensitivity C-Reactive Protein and Blood Pressure among Children with History of Low Birth Weight Appropriate for Gestational Age, Low Birth Weight Small for Gestational Age, and Normal Birth Weight in Manado, North Sulawesi.International journal of nephrology · 2019Article
- Small for gestational age and obesity related comorbidities.Annals of pediatric endocrinology & metabolism · 2018Review
- Antenatal corticosteroids and cardiometabolic outcomes in adolescents born with very low birth weight.Pediatric research · 2017Observational
- Relationship Between Birth Weight and the Double Product in Childhood, Adolescence, and Adulthood (from the Bogalusa Heart Study).The American journal of cardiology · 2017Article
- Risk of low birth weight on adulthood hypertension - evidence from a tertiary care hospital in a South Asian country, Sri Lanka: a retrospective cohort study.BMC public health · 2017Article
- Relation of Birth Weight to Heart Rate in Childhood, Adolescence, and Adulthood (from the Bogalusa Heart Study).The American journal of cardiology · 2016Article
- A life course approach to cardiovascular aging.Future cardiology · 2015Article
- Review
- Neighborhood poverty, allostatic load, and birth outcomes in African American and white women: findings from the Bogalusa Heart Study.Health & place · 2013Article
- Blood pressure relation to body composition and age: analysis of a nurse-led investigation and consultation program.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesAlthough low birthweight is associated with elevated blood pressure (BP) levels, whether the strength of this relationship is amplified with age is still debated. This study tested the hypothesis that the magnitude of the birthweight-BP association increases with age from childhood to adulthood.
methodsThe study cohort included 6251 individuals (64.5% whites and 35.6% blacks, 50.0% males) enrolled in the Bogalusa Heart Study. Individuals were examined 1-15 times for BP from childhood to adulthood, with 24 363 observations. Information on birthweight and gestational age was obtained from Louisiana State birth certificates.
resultsAfter adjusting for race, sex, age and gestational age, low birthweight (kg) was associated with higher SBP levels (mmHg) in adolescence (aged 12-17 years, regression coefficient β = -0.80, P = 0.004) and adulthood (aged 18-50 years, β = -1.34, P = 0.010). Adjustment for current BMI yielded considerably stronger association. Importantly, the magnitude of the birthweight-SBP relationship, measured as standardized β(unit = SD), was significantly amplified with increasing age, regardless of adjustment for current BMI and race. Further, the strengthened association (the increase in standardized β ranging 0.02-0.12) by adjustment for current BMI was closely related to the BMI-SBP and birthweight-BMI correlations, especially noted in childhood.
conclusionThese findings on the potentiating effect of increasing age on the birthweight-BP relationship suggest that the fetal programming and the increasing cumulative burden with age of unhealthy lifestyle behaviors affect the development of adult hypertension in a synergistic manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.