ReviewCurrent opinion in organ transplantation2010
The impact of Th17 cells on transplant rejection and the induction of tolerance.
Review in Current opinion in organ transplantation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- The ratio of circulating regulatory T cells (Tregs)/Th17 cells is associated with acute allograft rejection in liver transplantation.PloS one · 2014Trial
- Trial
- An analysis of regulatory T-cell and Th-17 cell dynamics during cytomegalovirus replication in solid organ transplant recipients.PloS one · 2012Trial
- Molecular Mechanism for the Selective Presentation of Antigenic Peptides by Major Histocompatibility Complex Class I and Class II Molecules: A Hypothesis.Current issues in molecular biology · 2025Article
- Reduced T-Cell stemness underlies Th17 expansion and graft dysfunction in kidney transplant recipients.Frontiers in genetics · 2025Article
- Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions.Frontiers in immunology · 2024Review
- Polyfunctional donor-reactive T cells are associated with acute T-cell-mediated rejection of the kidney transplant.Clinical and experimental immunology · 2023Article
- Sertoli Cells Express Accommodation, Survival, and Immunoregulatory Factors When Exposed to Normal Human Serum.Biomedicines · 2023Article
- Distinct T helper cell-mediated antitumor immunity: T helper 2 cells in focus.Cancer pathogenesis and therapy · 2023Review
- Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage.Journal of clinical medicine · 2022Article
- The CD226/TIGIT axis is involved in T cell hypo-responsiveness appearance in long-term kidney transplant recipients.Scientific reports · 2022Article
- Rocaglamide Prolonged Allograft Survival by Inhibiting Differentiation of Th1/Th17 Cells in Cardiac Transplantation.Oxidative medicine and cellular longevity · 2022Article
- Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection.Transplantation direct · 2021Article
- Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation.Frontiers in immunology · 2021Article
- Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF).Geburtshilfe und Frauenheilkunde · 2020Article
- Regulatory effect of rat bone marrow mesenchymal stem cells on Treg/Th17 immune balance in vitro.Molecular medicine reports · 2020Article
- In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation.Science advances · 2020Article
- The Immunological Basis of Liver Allograft Rejection.Frontiers in immunology · 2020Review
- Magnetic resonance imaging of stem cell-macrophage interactions with ferumoxytol and ferumoxytol-derived nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- The parallel paradigm between intestinal transplant inflammation and inflammatory bowel disease.Current opinion in organ transplantation · 2019Review
Corrections and comments
- Erratum issuedSan, David [corrected to Segundo, David San]
Authors and funding
5 authors.
Funding
Abstract
purpose of reviewThis review aims to provide an overview of the latest evidence for the involvement of Th17 cells in the rejection of solid organ allografts. It will also consider the implications of the relationship between the differentiation pathways of Th17 and regulatory T cells (Tregs), as well as their plasticity in the context of transplantation tolerance. RECENT
findingsIn the absence of the Th1 lineage in vivo, Th17 cells are capable of rejecting cardiac allografts, showing the capacity of Th17 cells to cause allograft rejection, at least in experimental models. Th17 cells are relatively unsusceptible to suppression by Tregs, although this may be context dependent. Furthermore, addition of inflammatory signals to a Treg-inducing environment leads to Th17 development and established Tregs can be converted to Th17 cells under inflammatory conditions. SUMMARY: The capacity of Th17 cells to cause allograft rejection is becoming increasingly clear. However, the role and contribution of Th17 cells in allograft rejection in the presence of the full orchestra of T helper cells remains elusive. The apparent resistance of Th17 to be suppressed by Tregs may pose a hurdle for effective immunosuppression and tolerance inducing protocols. Furthermore, the close developmental pathways of Th17 and Tregs and the ability of Tregs to convert into Th17 cells in the presence of inflammatory signals may impede the establishment of specific unresponsiveness to donor alloantigens in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.