Trial reportMenopause (New York, N.Y.)2010
Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: a pilot study.
Trial report in Menopause (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Cognitive complaints are associated with smaller right medial temporal gray-matter volume in younger postmenopausal women.Menopause (New York, N.Y.) · 2020Trial
- An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.British journal of clinical pharmacology · 2017Trial
- Estradiol treatment altered anticholinergic-related brain activation during working memory in postmenopausal women.NeuroImage · 2012Trial
- Home-cage pharmacology in marmosets: behavioral effects of scopolamine.Psychopharmacology · 2026Article
- Scopolamine induced learning deficit in marmosets.Research square · 2025Article
- Scopolamine induced learning deficit in marmosets.bioRxiv : the preprint server for biology · 2025Article
- Age Impacts the Burden That Reference Memory Imparts on an Increasing Working Memory Load and Modifies Relationships With Cholinergic Activity.Frontiers in behavioral neuroscience · 2021Article
- Anticholinergic Amnesia is Mediated by Alterations in Human Network Connectivity Architecture.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.Human brain mapping · 2019Article
- Estrogen-cholinergic interactions: Implications for cognitive aging.Hormones and behavior · 2015Review
- Potential therapeutic uses of mecamylamine and its stereoisomers.Pharmacology, biochemistry, and behavior · 2013Review
- Cholinergic Enhancement of Brain Activation in Mild Cognitive Impairment during Episodic Memory Encoding.Frontiers in psychiatry · 2013Article
- Hormonal environment affects cognition independent of age during the menopause transition.The Journal of clinical endocrinology and metabolism · 2012Article
- Functional brain imaging of nicotinic effects on higher cognitive processes.Biochemical pharmacology · 2011Review
- Cholinergic modulation of cognition: insights from human pharmacological functional neuroimaging.Progress in neurobiology · 2011Review
- The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation.Pharmacology, biochemistry, and behavior · 2011Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe cholinergic system has been shown to modulate estrogen effects on cognitive performance in postmenopausal women. In an effort to further understand cholinergic contributions to cognition after menopause, this pilot study investigated the effects of two receptor-specific anticholinergic drugs on brain activation and episodic memory encoding in postmenopausal women not taking estrogen.
methodsSix healthy postmenopausal women took part in three drug challenges using the antimuscarinic drug scopolamine (2.5 microg/kg IV), the antinicotinic drug mecamylamine (20 mg PO), and placebo. During functional magnetic resonance imaging, participants performed a visual-verbal continuous recognition memory test that allowed for the separation of encoding and recognition processes.
resultsFunctional magnetic resonance imaging results showed greater hippocampal and frontal activation and less occipital activation during encoding relative to retrieval conditions. This pattern of activation was similar under both drug challenges.
conclusionsThese results suggest that the changes in the cholinergic system may, in part, be responsible for menopause-related increases in brain activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.