ArticleHuman reproduction (Oxford, England)2010
Predicting aneuploidy in human oocytes: key factors which affect the meiotic process.
Article in Human reproduction (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 87 citations in OpenAlex.
- Embryo utilisation rate and transferable embryo to oocyte ratio correlate positively with livebirth rate but negatively with oocyte number: analysis of 14,156 fresh IVF/ICSI cycles.Journal of ovarian research · 2025Article
- Progestin-primed ovarian stimulation protocol in patients undergoing assisted reproductive technology.Frontiers in reproductive health · 2025Review
- Infertility following trisomic pregnancies: A nationwide cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis.Journal of clinical medicine · 2024Review
- Reproductive outcomes of single frozen-thawed embryo transfer in patients with endometriosis after preimplantation genetic testing.Journal of assisted reproduction and genetics · 2024Article
- Evaluation of Clinical Outcomes after Poor-Quality Embryo Transfer and Prognostic Parameters.Journal of clinical medicine · 2023Article
- Endometriosis, Oocyte, and Embryo Quality.Journal of clinical medicine · 2023Review
- Oocyte aneuploidy rates in river and swamp buffalo types (Bubalus bubalis) determined by Multi-color Fluorescence In Situ Hybridization (M-FISH).Scientific reports · 2022Article
- Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling CaCell proliferation · 2021Article
- Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes.Reproductive biology and endocrinology : RB&E · 2021Article
- Can Ratios Between Prognostic Factors Predict the Clinical Pregnancy Rate in an IVF/ICSI Program with a GnRH Agonist-FSH/hMG Protocol? An Assessment of 2421 Embryo Transfers, and a Review of the Literature.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Blastocyst Morphology Based on Uniform Time-Point Assessments is Correlated With Mosaic Levels in Embryos.Frontiers in genetics · 2021Article
- Telomere Dysfunction in Oocytes and Embryos From Obese Mice.Frontiers in cell and developmental biology · 2021Article
- Mathematical modeling of human oocyte aneuploidy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Endometriosis and cumulative live birth rate after fresh and frozen IVF cycles with single embryo transfer in young women: no impact beyond reduced ovarian sensitivity-a case control study.Journal of assisted reproduction and genetics · 2019Article
- Prediction of live birth and cumulative live birth rates in freeze-all-IVF treatment of a general population.Journal of assisted reproduction and genetics · 2019Article
- Comparison of Efficiencies of Non-invasive Prenatal Testing, Karyotyping, and Chromosomal Micro-Array for Diagnosing Fetal Chromosomal Anomalies in the Second and Third Trimesters.Frontiers in genetics · 2019Article
- Endometriosis Is a Cause of Infertility. Does Reactive Oxygen Damage to Gametes and Embryos Play a Key Role in the Pathogenesis of Infertility Caused by Endometriosis?Frontiers in endocrinology · 2018Review
- GTPase-activating protein Elmod2 is essential for meiotic progression in mouse oocytes.Cell cycle (Georgetown, Tex.) · 2017Article
- A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos.BioMed research international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo estimate the incidence of aneuploidy in relation to patients' characteristics, the type of hormonal stimulation and their response to induction of multiple follicular growth, 4163 first polar bodies (PB1s) were analyzed.
methodsFive hundred and forty four infertile couples underwent 706 assisted conception cycles (640 with poor prognosis indications and 66 controls) in which chromosomal analysis of PB1 for the chromosomes 13, 15, 16, 18, 21 and 22 was performed. Results were evaluated in a multivariate analysis.
resultsThe proportion of normal oocytes was directly correlated (P < 0.01) with (i) the number of mature oocytes and (ii) the establishment of a clinical pregnancy; and inversely correlated (P < 0.01) with (i) female age, (ii) causes of female infertility (endometriosis, abortions, ovulatory factor), (iii) poor prognosis indications (female age, number of previous cycles, multiple poor prognosis indications), (iv) number of FSH units per oocyte and (v) number of FSH units per metaphase II oocyte. There was a weak significance of frequency (P < 0.05) between type of abnormality (originated by chromatid predivision, chromosome non-disjunction or combined mechanisms in the same oocyte) and groups of the studied variables, rather than to a specific abnormality or a specific chromosome.
conclusionsThe type of infertility had a significant effect on errors derived from the first meiotic division, whose incidence was significantly higher in the presence of endometriosis or of an ovulatory factor, and in women that experienced repeated abortions. Each aneuploidy event was found to be dependent not on a specific variable, but on groups of variables. In addition, the tendency of chromosomal abnormalities to occur simultaneously implies that the deriving aneuploidies can be of any type.
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