ReviewJournal of the National Cancer Institute2010
Breast tissue composition and susceptibility to breast cancer.
Review in Journal of the National Cancer Institute, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 244 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
244 citing papers in PubMed, 5 syntheses or guidelines pooled it, 475 citations in OpenAlex.
- The impact of mammographic breast density on locoregional recurrence in breast cancer: a systematic review and meta-analysis.Breast cancer research and treatment · 2025Pooled it
- Relationship Between Breast Density and Selective Estrogen-Receptor Modulators, Aromatase Inhibitors, Physical Activity, and Diet: A Systematic Review.Integrative cancer therapies · 2016Pooled it
- Mammographic density phenotypes and risk of breast cancer: a meta-analysis.Journal of the National Cancer Institute · 2014Pooled it
- Effect of preventive hormonal therapy on breast density: a systematic qualitative review.TheScientificWorldJournal · 2014Pooled it
- Association between vitamin D receptor gene Cdx2 polymorphism and breast cancer susceptibility.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Deep Learning Based on Automated Breast Volume Scanner Images for the Diagnosis of Breast Lesions: A Multicenter Diagnostic Study.International journal of medical sciences · 2025Trial
- Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women.Breast cancer research : BCR · 2024Trial
- The Influence of Vitamin D on Mammographic Density: Results from CALGB 70806 (Alliance) a Randomized Clinical Trial.Cancer prevention research (Philadelphia, Pa.) · 2021Trial
- Reproducible automated breast density measure with no ionizing radiation using fat-water decomposition MRI.Journal of magnetic resonance imaging : JMRI · 2018Trial
- A web-based personalized risk communication and decision-making tool for women with dense breasts: Design and methods of a randomized controlled trial within an integrated health care system.Contemporary clinical trials · 2017Trial
- Between-race differences in the effects of breast density information and information about new imaging technology on breast-health decision-making.Patient education and counseling · 2016Trial
- Estradiol-associated extracellular signaling in the human breastOncoimmunology · 2026Article
- Proteomic signatures identify significantly different inflammatory breast tissue microenvironments depending on mammographic density or estrogen exposure.NPJ breast cancer · 2026Article
- Tissue-stiffness-driven platelet activation emerges as a potential target for breast cancer prevention and treatment.Cell communication and signaling : CCS · 2026Article
- Deep learning models to predict mammographic density jointly on standard dose and low dose images.The British journal of radiology · 2026Article
- GuidedMorph: Two-Stage Deformable Registration for Breast MRI.IEEE journal of biomedical and health informatics · 2026Article
- An Unsupervised Deep Learning Framework for Quantitative Breast Density Estimation from Mammograms.Journal of imaging · 2026Article
- Advancements in Developing an Automated Breast Density Detection Technique for Breast Cancer Risk Prediction: Synthesizing a Signal-dependent Noise Stochastic Process.bioRxiv : the preprint server for biology · 2026Article
- Association between Participant Characteristics and Breast Parenchymal Texture Variation among Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- ABUS-based glandular tissue component classification for breast cancer risk prediction in Chinese women with dense breasts: a retrospective study.BMC medical imaging · 2026Article
184 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Breast density, as assessed by mammography, reflects breast tissue composition. Breast epithelium and stroma attenuate x-rays more than fat and thus appear light on mammograms while fat appears dark. In this review, we provide an overview of selected areas of current knowledge about the relationship between breast density and susceptibility to breast cancer. We review the evidence that breast density is a risk factor for breast cancer, the histological and other risk factors that are associated with variations in breast density, and the biological plausibility of the associations with risk of breast cancer. We also discuss the potential for improved risk prediction that might be achieved by using alternative breast imaging methods, such as magnetic resonance or ultrasound. After adjustment for other risk factors, breast density is consistently associated with breast cancer risk, more strongly than most other risk factors for this disease, and extensive breast density may account for a substantial fraction of breast cancer. Breast density is associated with risk of all of the proliferative lesions that are thought to be precursors of breast cancer. Studies of twins have shown that breast density is a highly heritable quantitative trait. Associations between breast density and variations in breast histology, risk of proliferative breast lesions, and risk of breast cancer may be the result of exposures of breast tissue to both mitogens and mutagens. Characterization of breast density by mammography has several limitations, and the uses of breast density in risk prediction and breast cancer prevention may be improved by other methods of imaging, such as magnetic resonance or ultrasound tomography.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.