ArticleThe American journal of pathology2010
CD137 is required for M cell functional maturation but not lineage commitment.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Influence of Alcohol on the Intestinal Immune System.Alcohol research : current reviews · 2025Pooled it
- Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations.DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Pooled it
- Deciphering the M-cell niche: insights from mouse models on how microfold cells "know" where they are needed.Frontiers in immunology · 2024Review
- Cross-Talk Between the Intestinal Epithelium andFrontiers in microbiology · 2022Review
- Bacteroidetes Species Are Correlated with Disease Activity in Ulcerative Colitis.Journal of clinical medicine · 2021Article
- M Cells: Intelligent Engineering of Mucosal Immune Surveillance.Frontiers in immunology · 2019Review
- Inducible Colonic M Cells Are Dependent on TNFR2 but Not Ltβr, Identifying Distinct Signalling Requirements for Constitutive Versus Inducible M Cells.Journal of Crohn's & colitis · 2017Article
- Induction of Colonic M Cells during Intestinal Inflammation.The American journal of pathology · 2016Article
- CD137 signaling enhances tight junction resistance in intestinal epithelial cells.Physiological reports · 2014Article
- Epithelial microvilli establish an electrostatic barrier to microbial adhesion.Infection and immunity · 2014Article
- The development and function of mucosal lymphoid tissues: a balancing act with micro-organisms.Mucosal immunology · 2014Review
- Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA-microRNA regulatory network in nasopharyngeal carcinoma model systems.FEBS open bio · 2014Article
- Murine norovirus transcytosis across an in vitro polarized murine intestinal epithelial monolayer is mediated by M-like cells.Journal of virology · 2013Article
- Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium.Mucosal immunology · 2013Review
- Prion disease and the innate immune system.Viruses · 2012Review
- Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination.Immune network · 2012Article
- Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.Developmental and comparative immunology · 2012Article
- M cell targeting by a Claudin 4 targeting peptide can enhance mucosal IgA responses.BMC biotechnology · 2012Article
- Convergent and divergent development among M cell lineages in mouse mucosal epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Sampling of the intestinal microbiota by epithelial M cells.Current gastroenterology reports · 2010Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Mucosal immune surveillance depends on M cells that reside in the epithelium overlying Peyer's patch and nasopharyngeal associated lymphoid tissue to transport particles to underlying lymphocytes. M cell development is associated with B lymphocytes in a basolateral pocket, but the interactions between these cells are poorly understood. In a cell culture model of M cell differentiation, we found lymphotoxin/tumor necrosis factor alpha induction of CD137 (TNFRSF9) protein on intestinal epithelial cell lines, raising the possibility that CD137 on M cells in vivo might interact with CD137L expressed by B cells. Accordingly, while CD137-deficient mice produced UEA-1+ M cell progenitors in nasopharyngeal associated lymphoid tissue and Peyer's patch epithelium, they showed an abnormal morphology, including the absence of basolateral B cell pockets. More important, CD137-deficient nasopharyngeal associated lymphoid tissue M cells were defective in microparticle transcytosis. Bone marrow irradiation chimeras confirmed that while induction of UEA-1+ putative M cell precursors was not CD137-dependent, full M cell transcytosis function required expression of CD137 by radioresistant stromal cells as well as by bone marrow-derived cells. These results are consistent with a two-step model of M cell differentiation, with initial CD137-independent commitment to the M cell lineage followed by a CD137-CD137L interaction of M cells with CD137-activated B lymphocytes or dendritic cells for functional maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.