ArticleScience (New York, N.Y.)2010
High-resolution analysis of parent-of-origin allelic expression in the mouse brain.
Article in Science (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 295 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
295 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker.Nucleic acids research · 2017Pooled it
- Investigating the Contribution of the Imprinted Gene Asb4 to Parental Care.The European journal of neuroscience · 2026Article
- Article
- Machine learning-based gait classification and genome-wide association identify a QTL for gait type in Colombian paso horses.iScience · 2026Article
- A comprehensive genome-wide scan for parent-of-origin expressed genes in the pig clarifies the conservation landscape of genomic imprinting.Genetics, selection, evolution : GSE · 2026Article
- Plaque-associated Microglial Polarization in Visual Brain Regions of the 5xFAD Mouse Model.bioRxiv : the preprint server for biology · 2026Article
- The superpowers of imprinting control regions.Genome research · 2026Review
- How Imprinted Genes Shape Nurturing Behaviours and Neural Circuits.Brain, behavior and evolution · 2026Review
- Plaque-associated microglial polarization in visual brain regions of the 5xFAD mouse model.Frontiers in aging neuroscience · 2026Article
- Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion.PLoS genetics · 2025Article
- Sequence and parent-of-origin dependent mThe EMBO journal · 2025Article
- Evolutionary lineage-specific genomic imprinting at the ZNF791 locus.PLoS genetics · 2025Article
- Environmental epigenomics and the human imprintome.Environmental epigenetics · 2025Article
- Identification ofInternational journal of molecular sciences · 2024Article
- United by conflict: Convergent signatures of parental conflict in angiosperms and placental mammals.The Journal of heredity · 2024Review
- The Change Rate of theBiology · 2024Article
- Multi-omic characterization of allele-specific regulatory variation in hybrid pigs.Nature communications · 2024Article
- Characterization of dUTPase expression in mouse postnatal development and adult neurogenesis.Scientific reports · 2024Article
- Molecular and Therapeutic Roles of Non-Coding RNAs in Oral Cancer-A Review.Molecules (Basel, Switzerland) · 2024Review
235 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Genomic imprinting results in preferential expression of the paternal or maternal allele of certain genes. We have performed a genome-wide characterization of imprinting in the mouse embryonic and adult brain. This approach uncovered parent-of-origin allelic effects of more than 1300 loci. We identified parental bias in the expression of individual genes and of specific transcript isoforms, with differences between brain regions. Many imprinted genes are expressed in neural systems associated with feeding and motivated behaviors, and parental biases preferentially target genetic pathways governing metabolism and cell adhesion. We observed a preferential maternal contribution to gene expression in the developing brain and a major paternal contribution in the adult brain. Thus, parental expression bias emerges as a major mode of epigenetic regulation in the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.