ArticleProceedings of the National Academy of Sciences of the United States of America2010
Biological role of noise encoded in a genetic network motif.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs in three ray-finned fishes.bioRxiv : the preprint server for biology · 2026Article
- A logic-incorporated gene regulatory network deciphers principles in cell fate decisions.eLife · 2024Article
- Getting it right: suppression and leveraging of noise in robust decision-making.Quantitative plant biology · 2024Review
- Role of integrated noise in pathway-specific signal propagation in feed-forward loops.Theory in biosciences = Theorie in den Biowissenschaften · 2021Article
- Functional roles of microbial cell-to-cell heterogeneity and emerging technologies for analysis and control.Current opinion in microbiology · 2020Review
- Identifying functions and prognostic biomarkers of network motifs marked by diverse chromatin states in human cell lines.Oncogene · 2020Article
- Article
- Sensitivities of Regulation Intensities in Feed-Forward Loops with Multistability.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2019Article
- Feed-forward regulation adaptively evolves via dynamics rather than topology when there is intrinsic noise.Nature communications · 2019Article
- The Reaction of Dimerization by Itself Reduces the Noise Intensity of the Protein Monomer.Scientific reports · 2019Article
- Maximum Caliber Can Build and Infer Models of Oscillation in a Three-Gene Feedback Network.The journal of physical chemistry. B · 2019Article
- Perspective: Engineering noise in biological systems towards predictive stochastic design.APL bioengineering · 2018Article
- Organization of feed-forward loop motifs reveals architectural principles in natural and engineered networks.Science advances · 2018Article
- Role of noise and parametric variation in the dynamics of gene regulatory circuits.NPJ systems biology and applications · 2018Article
- Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.PloS one · 2018Article
- Detection of network motifs using three-way ANOVA.PloS one · 2018Article
- Building Predictive Models of Genetic Circuits Using the Principle of Maximum Caliber.Biophysical journal · 2017Article
- MIST1 and PTF1 Collaborate in Feed-Forward Regulatory Loops That Maintain the Pancreatic Acinar Phenotype in Adult Mice.Molecular and cellular biology · 2016Article
- Noise Expands the Response Range of the Bacillus subtilis Competence Circuit.PLoS computational biology · 2016Article
- Noise Decomposition Principle in a Coherent Feed-Forward Transcriptional Regulatory Loop.Frontiers in physiology · 2016Article
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Abstract
Genetic circuits that regulate distinct cellular processes can differ in their wiring pattern of interactions (architecture) and susceptibility to stochastic fluctuations (noise). Whether the link between circuit architecture and noise is of biological importance remains, however, poorly understood. To investigate this problem, we performed a computational study of gene expression noise for all possible circuit architectures of feed-forward loop (FFL) motifs. Results revealed that FFL architectures fall into two categories depending on whether their ON (stimulated) or OFF (unstimulated) steady states exhibit noise. To explore the biological importance of this difference in noise behavior, we analyzed 858 documented FFLs in Escherichia coli that were divided into 39 functional categories. The majority of FFLs were found to regulate two subsets of functional categories. Interestingly, these two functional categories associated with FFLs of opposite noise behaviors. This opposite noise preference revealed two noise-based strategies to cope with environmental constraints where cellular responses are either initiated or terminated stochastically to allow probabilistic sampling of alternative states. FFLs may thus be selected for their architecture-dependent noise behavior, revealing a biological role for noise that is encoded in gene circuit architectures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.