ArticleProceedings of the National Academy of Sciences of the United States of America2010
Double-stranded DNA homology produces a physical signature.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Direct evidence and quantification of homologous recognition between DNA duplexes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Paranemic Cohesion of DNA under Isothermal Conditions.JACS Au · 2026Article
- Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organization.NAR genomics and bioinformatics · 2025Article
- Controlled Reassociation of Multistranded, Polycrossover DNA Molecules into Double Helices.Nano letters · 2025Article
- The emerging sequence grammar of 3D genome organisation.Human genetics · 2025Review
- Folding Competition and Dynamic Transformation in DNA Origami: Parallel Versus Antiparallel Crossovers.Small methods · 2025Article
- The unusual structural properties and potential biological relevance of switchback DNA.Nature communications · 2024Article
- Engineering tertiary chirality in helical biopolymers.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The unusual structural properties and potential biological relevance of switchback DNA.bioRxiv : the preprint server for biology · 2024Article
- Homologous pairing in short double-stranded DNA-grafted colloidal microspheres.Biophysical journal · 2022Article
- Recombination-independent recognition of DNA homology for meiotic silencing inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Exceptional Nuclease Resistance of Paranemic Crossover (PX) DNA and Crossover-Dependent Biostability of DNA Motifs.Journal of the American Chemical Society · 2020Article
- Complex between a Multicrossover DNA Nanostructure, PX-DNA, and T7 Endonuclease I.Biochemistry · 2019Article
- Recombination-Independent Recognition of DNA Homology for Repeat-Induced Point Mutation (RIP) Is Modulated by the Underlying Nucleotide Sequence.PLoS genetics · 2016Article
- The unusual and dynamic character of PX-DNA.Nucleic acids research · 2015Article
- Direct recognition of homology between double helices of DNA in Neurospora crassa.Nature communications · 2014Article
- Top3α is required during the convergent migration step of double Holliday junction dissolution.PloS one · 2014Article
- Stress-induced condensation of bacterial genomes results in re-pairing of sister chromosomes: implications for double strand DNA break repair.The Journal of biological chemistry · 2013Article
- Site-specific inter-strand cross-links of DNA duplexes.Chemical science · 2013Article
- Bullied no more: when and how DNA shoves proteins around.Quarterly reviews of biophysics · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA is found in the cell largely as a negatively supercoiled molecule. This high-energy form of the genetic material can engender sequence-dependent structures, such as cruciforms, Z-DNA, or H-DNA, even though they are not favored by conventional conditions in relaxed DNA. A key feature of DNA in living systems is the presence of homology. We have sought homology-dependent structural phenomena based on topological relaxation. Using two-dimensional electrophoresis, we demonstrate a structural transition in supercoiled plasmid molecules containing homologous segments. Atomic force microscopy (AFM) reveals a dumbbell structure in molecules whose linking difference is beyond the transition point. The position of the dumbbell shaft is a function of the site of homology, and its extent is proportional to the linking difference. Second-site-reversion electrophoresis data support the notion that the shaft contains PX-DNA. Predicted cross-linking patterns generated in vivo suggest that homology-dependent structures can occur within the cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.