ArticleProceedings of the National Academy of Sciences of the United States of America2010
Interneurons of the cerebellar cortex toggle Purkinje cells between up and down states.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.The Journal of general physiology · 2023Article
- Selective loss of the GABAJournal of neurophysiology · 2020Article
- Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.Cell reports · 2020Article
- Long Pauses in Cerebellar Interneurons in Anesthetized Animals.Cerebellum (London, England) · 2017Article
- Inhibition promotes long-term potentiation at cerebellar excitatory synapses.Scientific reports · 2016Article
- Inverse Stochastic Resonance in Cerebellar Purkinje Cells.PLoS computational biology · 2016Article
- Voltage imaging to understand connections and functions of neuronal circuits.Journal of neurophysiology · 2016Review
- Article
- Electrophysiological and Immunohistochemical Evidence for an Increase in GABAergic Inputs and HCN Channels in Purkinje Cells that Survive Developmental Ethanol Exposure.Cerebellum (London, England) · 2015Article
- Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells.Nature communications · 2015Article
- Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules.Journal of neurophysiology · 2015Article
- Bidirectional modulation of deep cerebellar nuclear cells revealed by optogenetic manipulation of inhibitory inputs from Purkinje cells.Neuroscience · 2014Article
- Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus.Journal of neurophysiology · 2014Article
- Emergence of a 600-Hz buzz UP state Purkinje cell firing in alert mice.Neuroscience · 2014Article
- HCN1 channels in cerebellar Purkinje cells promote late stages of learning and constrain synaptic inhibition.The Journal of physiology · 2013Article
- Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation.Frontiers in neural circuits · 2013Article
- Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Storage of correlated patterns in standard and bistable Purkinje cell models.PLoS computational biology · 2012Article
- Sensory integration, sensory processing, and sensory modulation disorders: putative functional neuroanatomic underpinnings.Cerebellum (London, England) · 2011Review
- Signals and circuits in the purkinje neuron.Frontiers in neural circuits · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate that single interneurons can toggle the output neurons of the cerebellar cortex (the Purkinje cells) between their two states. The firing of Purkinje cells has previously been shown to alternate between an "up" state in which the cell fires spontaneous action potentials and a silent "down" state. We show here that small hyperpolarizing currents in Purkinje cells can bidirectionally toggle Purkinje cells between down and up states and that blockade of the hyperpolarization-activated cation channels (H channels) with the specific antagonist ZD7288 (10 microM) blocks the transitions from down to up states. Likewise, hyperpolarizing inhibitory postsnyaptic potentials (IPSPs) produced by small bursts of action potentials (10 action potentials at 50 Hz) in molecular-layer interneurons induce these bidirectional transitions in Purkinje cells. Furthermore, single interneurons in paired interneuron --> Purkinje cell recordings, produce bidirectional switches between the two states of Purkinje cells. The ability of molecular-layer interneurons to toggle Purkinje cells occurs when Purkinje cells are recorded under whole-cell patch-clamp conditions as well as when action potentials are recorded in an extracellular loose cell-attached configuration. The mode switch demonstrated here indicates that a single presynaptic interneuron can have opposite effects on the output of a given Purkinje cell, which introduces a unique type of synaptic interaction that may play an important role in cerebellar signaling.
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