ArticleProceedings of the National Academy of Sciences of the United States of America2010
Long-range function of an intergenic retrotransposon.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 79 citations in OpenAlex.
- Transcriptional landscapes of dengue patients reveal associations between HERV activity and disease severity.NAR molecular medicine · 2026Article
- Human Endogenous Retroviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Emerging Roles in Pathogenesis, Immunity, Biomarkers and Therapeutics.International journal of molecular sciences · 2026Review
- Binding of NF-Y to transposable elements in mouse and human cells.Mobile DNA · 2025Article
- Transposable elements as genome regulators in normal and malignant haematopoiesis.Blood cancer journal · 2025Review
- Viral influencers: deciphering the role of endogenous retroviral LTR12 repeats in cellular gene expression.Journal of virology · 2025Review
- Article
- Endogenous retroviral solo-LTRs in human genome.Frontiers in genetics · 2024Review
- Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers.Mobile DNA · 2023Article
- Review
- Human Endogenous Retroviruses in Diseases.Sub-cellular biochemistry · 2023Article
- Roles of transposable elements in the regulation of mammalian transcription.Nature reviews. Molecular cell biology · 2022Review
- Evolution of mouse circadian enhancers from transposable elements.Genome biology · 2021Article
- Article
- Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression.Science advances · 2020Article
- RNA-Seq Transcriptome Analysis Reveals Long Terminal Repeat Retrotransposon Modulation in Human Peripheral Blood Mononuclear Cells afterJournal of virology · 2020Article
- Review
- Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia.Nature communications · 2020Article
- An LTR retrotransposon-derived lncRNA interacts with RNF169 to promote homologous recombination.EMBO reports · 2019Article
- Comprehensive Characterization of the Human Endogenous Retrovirus HERV-K(HML-6) Group: Overview of Structure, Phylogeny, and Contribution to the Human Genome.Journal of virology · 2019Article
- Systematic identification and characterization of regulatory elements derived from human endogenous retroviruses.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Retrotransposons including endogenous retroviruses and their solitary long terminal repeats (LTRs) compose >40% of the human genome. Many of them are located in intergenic regions far from genes. Whether these intergenic retrotransposons serve beneficial host functions is not known. Here we show that an LTR retrotransposon of ERV-9 human endogenous retrovirus located 40-70 kb upstream of the human fetal gamma- and adult beta-globin genes serves a long-range, host function. The ERV-9 LTR contains multiple CCAAT and GATA motifs and competitively recruits a high concentration of NF-Y and GATA-2 present in low abundance in adult erythroid cells to assemble an LTR/RNA polymerase II complex. The LTR complex transcribes intergenic RNAs unidirectionally through the intervening DNA to loop with and modulate transcription factor occupancies at the far downstream globin promoters, thereby modulating globin gene switching by a competitive mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.