ArticleThe Journal of biological chemistry2010
Characterization of C1q in teleosts: insight into the molecular and functional evolution of C1q family and classical pathway.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Immunomodulatory effects of dietary methionine supplementation in rainbow trout (Frontiers in immunology · 2025Article
- A Collagen10a1 mutation disrupts cell polarity in a medaka model for metaphyseal chondrodysplasia type Schmid.iScience · 2024Article
- Epigenetic regulation of complement C1Q gene expression.Frontiers in immunology · 2024Article
- The evolution of flexibility and function in the Fc domains of IgM, IgY, and IgE.Frontiers in immunology · 2024Article
- Complement System Inhibitory Drugs in a Zebrafish (International journal of molecular sciences · 2023Article
- Red blood cells in proliferative kidney disease-rainbow trout (Frontiers in immunology · 2023Article
- Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis.Journal of clinical and translational science · 2021Review
- Differential immune responses of immunoglobulin Z subclass members in antibacterial immunity in a zebrafish model.Immunology · 2021Article
- Molecular characterization of complement 9 in Epinephelus coioides and differential expression analysis of classical complement genes following Vibrio alginolyticus challenge.Ecotoxicology (London, England) · 2020Article
- Critical Role for a Subset of Intestinal Macrophages in Shaping Gut Microbiota in Adult Zebrafish.Cell reports · 2018Article
- Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model.Frontiers in immunology · 2018Article
- Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure.Frontiers in immunology · 2018Article
- MafB is a critical regulator of complement component C1q.Nature communications · 2017Article
- Crystal structure of zebrafish complement 1qA globular domain.Protein science : a publication of the Protein Society · 2016Article
- Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD.Acta crystallographica. Section F, Structural biology communications · 2014Article
- The innate immune-related genes in catfish.International journal of molecular sciences · 2012Review
- CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1.The Biochemical journal · 2012Article
- Viral diseases in zebrafish: what is known and unknown.ILAR journal · 2012Review
- Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages.The Journal of biological chemistry · 2011Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
C1qs are key components of the classical complement pathway. They have been well documented in human and mammals, but little is known about their molecular and functional characteristics in fish. In the present study, full-length cDNAs of c1qA, c1qB, and c1qC from zebrafish (Danio rerio) were cloned, revealing the conservation of their chromosomal synteny and organization between zebrafish and other species. For functional analysis, the globular heads of C1qA (ghA), C1qB (ghB), and C1qC (ghC) were expressed in Escherichia coli as soluble proteins. Hemolytic inhibitory assays showed that hemolytic activity in carp serum can be inhibited significantly by anti-C1qA, -C1qB, and -C1qC of zebrafish, respectively, indicating that C1qA, C1qB, and C1qC are involved in the classical pathway and are conserved functionally from fish to human. Zebrafish C1qs also could specifically bind to heat-aggregated zebrafish IgM, human IgG, and IgM. The involvement of globular head modules in the C1q-dependent classical pathway demonstrates the structural and functional conservation of these molecules in the classical pathway and their IgM or IgG binding sites during evolution. Phylogenetic analysis revealed that c1qA, c1qB, and c1qC may be formed by duplications of a single copy of c1qB and that the C1q family is, evolutionarily, closely related to the Emu family. This study improves current understanding of the evolutionary history of the C1q family and C1q-mediated immunity.
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