ArticleSleep2010
Benzodiazepine receptor agonists cause drug-specific and state-specific alterations in EEG power and acetylcholine release in rat pontine reticular formation.
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome.Molecular autism · 2021Article
- Eszopiclone and Zolpidem Produce Opposite Effects on Hippocampal Ripple Density.Frontiers in pharmacology · 2021Article
- Novel pharmacological treatments for generalized anxiety disorder: Pediatric considerations.Depression and anxiety · 2020Review
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- GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.The European journal of neuroscience · 2014Article
- Marine polyphenol phlorotannins promote non-rapid eye movement sleep in mice via the benzodiazepine site of the GABAA receptor.Psychopharmacology · 2014Article
- Benzodiazepine site agonists differentially alter acetylcholine release in rat amygdala.Anesthesia and analgesia · 2014Article
- Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome.Sleep · 2014Article
- Article
- GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.Brain research · 2013Article
- GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep.Sleep · 2012Article
- Neuropharmacology of Sleep and Wakefulness: 2012 Update.Sleep medicine clinics · 2012Article
- Buprenorphine disrupts sleep and decreases adenosine concentrations in sleep-regulating brain regions of Sprague Dawley rat.Anesthesiology · 2011Article
- Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during rapid eye movement sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neuropharmacology of Sleep and Wakefulness.Sleep medicine clinics · 2010Article
- GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications.Sleep · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesBenzodiazepine (BDZ) and non-benzodiazepine (NBDZ) hypnotics enhance GABAergic transmission and are widely used for the treatment of insomnia. In the pontine reticular formation (PRF), GABA inhibits rapid eye movement (REM) sleep and acetylcholine (ACh) release. No previous studies have characterized the effects of BDZ and NBDZ hypnotics on ACh release in the PRF. This study tested 2 hypotheses: (1) that microdialysis delivery of zolpidem, eszopiclone, and diazepam to rat PRF alters ACh release in PRF and electroencephalographic (EEG) delta power and (2) that intravenous (i.v.) administration of eszopiclone to non-anesthetized rat alters ACh release in the PRF, sleep, and EEG delta power.
designA within- and between-groups experimental design.
settingUniversity of Michigan. PATIENTS OR
participantsAdult male Crl:CD*(SD) (Sprague-Dawley) rats (n = 57).
interventionsIn vivo microdialysis of the PRF in rats anesthetized with isoflurane was used to derive the concentration-response effects of zolpidem, eszopiclone, and diazepam on ACh release. Chronically instrumented rats were used to quantify the effects of eszopiclone (3 mg/kg, i.v.) on ACh release in the PRF, sleep-wake states, and cortical EEG power. MEASUREMENTS AND
resultsACh release was significantly increased by microdialysis delivery to the PRF of zolpidem and eszopiclone but not diazepam. EEG delta power was increased by zolpidem and diazepam but not by eszopiclone administered to the PRF. Eszopiclone (i.v.) decreased ACh release in the PRF of both anesthetized and non-anesthetized rats. Eszopiclone (i.v.) prevented REM sleep and increased EEG delta power.
conclusionThe concentration-response data provide the first functional evidence that multiple GABA(A) receptor subtypes are present in rat PRF. Intravenously administered eszopiclone prevented REM sleep, decreased ACh release in the PRF, and increased EEG delta power. The effects of eszopiclone are consistent with evidence that ACh release in the PRF is lower during NREM sleep than during REM sleep, and with data showing that cholinergic stimulation of the PRF activates the cortical EEG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.