ArticleSleep2010
Metabolic response of the cerebral cortex following gentle sleep deprivation and modafinil administration.
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Protein Targeting to Glycogen (PTG): A Promising Player in Glucose and Lipid Metabolism.Biomolecules · 2022Review
- Review
- Sleep and Wake Affect Glycogen Content and Turnover at Perisynaptic Astrocytic Processes.Frontiers in cellular neuroscience · 2018Article
- Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.Translational psychiatry · 2017Article
- Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes.IBRO reports · 2016Article
- Functions and Mechanisms of Sleep.AIMS neuroscience · 2016Article
- Effects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies.BMC biology · 2015Article
- Glycogen metabolism and the homeostatic regulation of sleep.Metabolic brain disease · 2015Review
- Sleep restriction impairs blood-brain barrier function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mice with altered brain lipoprotein metabolism display maladaptive responses to environmental challenges that may predispose to weight gain.Metabolic syndrome and related disorders · 2014Article
- A review of sleep deprivation studies evaluating the brain transcriptome.SpringerPlus · 2014Review
- Article
- Effects of sleep deprivation on brain bioenergetics, sleep, and cognitive performance in cocaine-dependent individuals.TheScientificWorldJournal · 2013Article
- Sleep/wake dependent changes in cortical glucose concentrations.Journal of neurochemistry · 2013Article
- Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway.Journal of neuroinflammation · 2012Article
- A metabolic-transcriptional network links sleep and cellular energetics in the brain.Pflugers Archiv : European journal of physiology · 2012Review
- Delta oscillations induced by ketamine increase energy levels in sleep-wake related brain regions.Neuroscience · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesThe main energy reserve of the brain is glycogen, which is almost exclusively localized in astrocytes. We previously reported that cerebral expression of certain genes related to glycogen metabolism changed following instrumental sleep deprivation in mice. Here, we extended our investigations to another set of genes related to glycogen and glucose metabolism. We also compared the effect of instrumentally and pharmacologically induced prolonged wakefulness, followed (or not) by 3 hours of sleep recovery, on the expression of genes related to brain energy metabolism.
designSleep deprivation for 6-7 hours.
settingAnimal sleep research laboratory.
participantsAdults OF1 mice.
interventionsWakefulness was maintained by "gentle sleep deprivation" method (GSD) or by administration of the wakefulness-promoting drug modafinil (MOD) (200 mg/kg i.p.). MEASUREMENTS AND
resultsLevels of mRNAs encoding proteins related to energy metabolism were measured by quantitative real-time PCR in the cerebral cortex. The mRNAs encoding protein targeting to glycogen (PTG) and the glial glucose transporter were significantly increased following both procedures used to prolong wakefulness. Glycogenin mRNA levels were increased only after GSD, while neuronal glucose transporter mRNA only after MOD. These effects were reversed after sleep recovery. A significant enhancement of glycogen synthase activity without any changes in glycogen levels was observed in both conditions.
conclusionsThese results indicate the existence of a metabolic adaptation of astrocytes aimed at maintaining brain energy homeostasis during the sleep-wake cycle.
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