The trouble with Tribbles: do antibodies against TRIB2 cause narcolepsy?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed.

1. The Role of T Cells in the Pathogenesis of Narcolepsy Type 1: A Narrative Review.International journal of molecular sciences · 2024
   Review
2. Autoimmune Disorders of the Nervous System: Pathophysiology, Clinical Features, and Therapy.Frontiers in neurology · 2021
   Review
3. HLA-DQB1*06:02 allele frequency and clinic-polysomnographic features in Saudi Arabian patients with narcolepsy.Sleep & breathing = Schlaf & Atmung · 2019
   Article
4. Unmet needs of patients with narcolepsy: perspectives on emerging treatment options.Nature and science of sleep · 2015
   Review
5. Narcolepsy - Between the dream and reality.Sleep science (Sao Paulo, Brazil) · 2014
   Article
6. Narcolepsy and A(H1N1)pdm09 vaccination: shaping the research on the observed signal.Human vaccines & immunotherapeutics · 2014
   Article
7. The autoimmune basis of narcolepsy.Current opinion in neurobiology · 2013
   Review
8. Genetic and immunologic aspects of sleep and sleep disorders.Chest · 2013
   Review
9. Genome-wide association study of sleep in Drosophila melanogaster.BMC genomics · 2013
   Article
10. Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation.Genes & development · 2013
    Article
11. Control of sleep and wakefulness.Physiological reviews · 2012
    Review
12. Narcolepsy in the pediatric population.Current neurology and neuroscience reports · 2012
    Article
13. Genetics of sleep and sleep disorders.Cell · 2011
    Review
14. Sleep state switching.Neuron · 2010
    Review

Corrections and comments

• Comment on
  Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy.2010
• Comment on
  Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy.2010

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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