ArticleWorld journal of gastroenterology2010
Nardostachys jatamansi extract protects against cytokine-induced beta-cell damage and streptozotocin-induced diabetes.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
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- Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2.Saudi journal of biological sciences · 2021Article
- Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Liquid Chromatography-Tandem Mass Spectrometry of Desoxo-Narchinol a and Its Pharmacokinetics and Oral Bioavailability in Rats and Mice.Molecules (Basel, Switzerland) · 2019Article
- Desoxo-narchinol A and Narchinol B Isolated from Nardostachys jatamansi Exert Anti-neuroinflammatory Effects by Up-regulating of Nuclear Transcription Factor Erythroid-2-Related Factor 2/Heme Oxygenase-1 Signaling.Neurotoxicity research · 2019Article
- Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites fromMolecules (Basel, Switzerland) · 2018Article
- Combination of Obestatin and Bone Marrow Mesenchymal Stem Cells Prevents Aggravation of Endocrine Pancreatic Damage in Type II Diabetic Rats.International journal of stem cells · 2017Article
- Beneficial Effects of Fractions of Nardostachys jatamansi on Lipopolysaccharide-Induced Inflammatory Response.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Achillea Millefolium L. Hydro- Alcoholic Extract Protects Pancreatic Cells by Down Regulating IL- 1β and iNOS Gene Expression in Diabetic Rats.International journal of molecular and cellular medicine · 2014Article
- Nardosinone protects H9c2 cardiac cells from angiotensin II-induced hypertrophy.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2013Article
- Nardostachys jatamansi protects against cold restraint stress induced central monoaminergic and oxidative changes in rats.Neurochemical research · 2012Article
- Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases.Experimental and therapeutic medicine · 2012Article
- Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis.World journal of gastroenterology · 2012Article
- Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.Current drug targets · 2011Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE).
methodsMice were injected with streptozotocin via a tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin-1beta and interferon-gamma to induce cytotoxicity.
resultsTreatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was confirmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were completely abolished when mice were pretreated with NJE. Inhibition of streptozotocin-induced hyperglycemia by NJE was mediated by suppression of nuclear factor (NF)-kappaB activation. In addition, NJE protected against cytokine-mediated cytotoxicity. Incubation of RINm5F cells and islets with NJE resulted in a significant reduction in cytokine-induced NF-kappaB activation and downstream events, inducible nitric oxide synthase expression and nitric oxide production. The protective effect of NJE was further demonstrated by the normal insulin secretion of cytokine-treated islets in response to glucose.
conclusionNJE provided resistance to pancreatic beta-cell damage from cytokine or streptozotocin treatment. The beta-cell protective effect of NJE is mediated by suppressing NF-kappaB activation.
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