ReviewWorld journal of gastroenterology2010
Helicobacter pylori and gastric cancer in the Middle East: a new enigma?
Review in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Estimates of the global burden of HIV-attributable and all-cause AIDS-defining cancers: a population-based modeling study.Frontiers in public health · 2026Pooled it
- Helicobacter pylori eradication in the face of escalating anti-microbial resistance: Geographic heterogeneity and emerging treatment strategies.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- Factors Associated with Malignant Gastric Ulcers: A 10-year Retrospective Cohort Study.International journal of general medicine · 2026Article
- Allelic Variation ofMicroorganisms · 2025Article
- Article
- A study of prevalence and risk factors forArchives of Razi Institute · 2024Article
- Association between country of birth and gastric intestinal metaplasia: a retrospective cohort study.Lancet regional health. Americas · 2023Article
- Study ofCancers · 2023Article
- Linking dysbiosis to precancerous stomach through inflammation: Deeper than and beyond imaging.Frontiers in immunology · 2023Review
- The adoption of artificial intelligence assisted endoscopy in the Middle East: challenges and future potential.Translational gastroenterology and hepatology · 2023Review
- Demographic Profile of Gastric Cancer in Afghanistan.Indian journal of surgical oncology · 2020Article
- Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort Study.Gastroenterology · 2020Article
- Gastric cancer & prospects of cancer in Saudi Arabia peninsula.Saudi journal of biological sciences · 2019Review
- The analysis of virulence factors and antibiotic resistance between Helicobacter pylori strains isolated from gastric antrum and body.BMC gastroenterology · 2019Article
- Non-Hodgkin Lymphoma in the Middle East Is Characterized by Low Incidence Rates With Advancing Age.Journal of global oncology · 2019Article
- Trends and Risk Factors of Gastric Cancer in Iran (2005-2010).International journal of preventive medicine · 2019Article
- Epidemiologic characteristics of gastric malignancies among Jordan University Hospital patients.Saudi medical journal · 2017Article
- Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer.World journal of microbiology & biotechnology · 2016Article
- Five year monitoring of considerable changes in tyrosine phosphorylation motifs of Helicobacter pylori cagA gene in Iran.Journal of applied genetics · 2015Article
- Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction.International journal of genomics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Middle East is the home of ethnic groups from three main backgrounds: Semitic (Arabs and Jews), Indo-European (Persians and Kurdish) and Turkic (Turkish and Turkmens). Its geographic location, which has been under continuous influences from Asia, Europe and Africa, has made it an ideal site for epidemiological studies on Helicobacter pylori (H. pylori) infection and genotyping. The gastric cancer rate differs in this region from very high in Iran (26.1/10(5)) to low in Israel (12.5/10(5)) and very low in Egypt (3.4/10(5)). Epidemiological studies showed that the prevalence of H. pylori is almost similar in those countries with a high level of infection in childhood. Importantly, the frequency of vacA s1 and m1 regions and cagA+ genotypes were higher in non Semitic populations who inhabit the North than Semitic populations, the inhabitants of Southern parts of the Middle East. H. pylori infection prevalence, distribution pattern of virulence factors, diet and smoking could not have explained the difference in cancer rate. This reflects the multifactorial aetiology of gastric cancer and suggests that H. pylori infection does not always directly correlate with the risk for gastrointestinal disease, such as gastric cancer. Further detailed investigations and international comparative studies of each risk factor need to be performed to investigate whether this represents a true enigma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.