ArticleHead and neck pathology2008
Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases.
Article in Head and neck pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Mitochondrial D-loop variants and copy number alterations in saliva of basaloid squamous cell carcinoma patient: Can it be worth as a prognostic value? Case report.International journal of surgery case reports · 2025Article
- Intraoral Basal Cell Carcinoma of Soft Palate: A Diagnostic Dilemma and Review of Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Bell's palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature.EXCLI journal · 2023Article
- Metastatic basal cell carcinoma of buccal mucosa: a report of a rare case.World journal of surgical oncology · 2022Article
- Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Identification of potential gene drivers of cutaneous squamous cell carcinoma: Analysis of microarray data.Medicine · 2020Article
- Basaloid Squamous Cell Carcinoma of Tonsil: an Unusual and Aggressive Variant.Indian journal of surgical oncology · 2019Article
- Detection of Felis catus papillomavirus type 2 within multicentric basosquamous carcinoma in a domestic cat.The Journal of veterinary medical science · 2018Article
- Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus.Journal of pathology and translational medicine · 2017Article
- Intraoral basal cell carcinoma, a rare neoplasm: report of three new cases with literature review.Head and neck pathology · 2014Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Diagnosis of basaloid squamous carcinoma (BSCC) currently relies mainly on histological criteria, with variable immunohistochemical results reported in small series. We explored the use of a battery of immunohistochemical stains to elucidate this diagnosis on 45 cases of BSCC. To further elucidate the immunohistochemical profile of BSCC, to explore potential genetic pathways of malignant transformation using proliferation markers, and to investigate a possible link with Human Papillomavirus (HPV). Forty-five cases of BSCC and 34 site-matched cases of squamous cell carcinoma (SCC) were obtained from the archives of the pathology department at our institution. Extensive literature review was undertaken utilizing Medline. Ber-EP4 is a useful diagnostic marker for BSCC, positive in 82% (37/45) of the cases and in 68% (23/34) of SCC. An alternative is the combination of cytokeratins CK14 and CK7, known to be negative, and CK1, known to be positive, which achieves an accuracy of 73% (33/45) in BSCC and 88% (30/34) in SCC. The two diagnostic approaches were in agreement in 66% of the cases; both methods were equally accurate in the divergent cases. Increased expression of the proliferation markers supports the concept that BSCC is a rapidly growing tumor. Results of p16 stains support an etiological link between BSCC and HPV; interestingly, HPV was present significantly more in BSCC (71% (32/45)), than in SCC (59% (20/34)) in this study (P=0.02).
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