ArticleMycopathologia2010
Antifungal activity of baicalein against Candida krusei does not involve apoptosis.
Article in Mycopathologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 52 citations in OpenAlex.
- The antibacterial activity, action mechanisms and prospects of Baicalein as an antibacterial adjuvant.World journal of microbiology & biotechnology · 2025Review
- Baicalein as a potent antifungal agent againstFrontiers in microbiology · 2025Article
- Activity of thonningianin A against Candida albicans in vitro and in vivo.Applied microbiology and biotechnology · 2024Article
- Inhibition ofFoods (Basel, Switzerland) · 2023Article
- The Chitosan-Based System withPharmaceutics · 2022Article
- An ethnopharmacological review on the therapeutical properties of flavonoids and their mechanisms of actions: A comprehensive review based on up to date knowledge.Toxicology reports · 2022Review
- Composition and Biological Activity ofMicroorganisms · 2021Article
- Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLP-Induced Inflammatory Response.Investigative ophthalmology & visual science · 2021Article
- Anti-Fungal Efficacy and Mechanisms of Flavonoids.Antibiotics (Basel, Switzerland) · 2020Review
- An Integrated Approach to Recognize Potential Protective Effects of Culinary Herbs Against Chronic Diseases.Journal of healthcare informatics research · 2019Article
- Activity of Polyphenolic Compounds against Candida glabrata.Molecules (Basel, Switzerland) · 2015Article
- Potential Use of Phenolic Acids as Anti-Candida Agents: A Review.Frontiers in microbiology · 2015Review
- Article
- The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was designed to evaluate the antifungal activity of baicalein against Candida krusei isolates. Using a broth microdilution assay, baicalein exhibited potent in vitro antifungal activity against C. krusei isolates with a minimum inhibitory concentration of 2.7 μg/ml. Flow cytometric study indicated that baicalein depolarized mitochondrial membrane potential in a concentration-dependent manner. However, mechanistic analyses showed that the intracellular reactive oxygen species (ROS) level was virtually unchanged, and massive DNA fragmentation was not observed in C. krusei isolates after baicalein treatment even at a concentration which was apoptotic in C. albicans. Taken together, we conclude that the antifungal activity of baicalein in C. krusei isolates occurs through perturbation in mitochondrial homeostasis without causing elevation of the intracellular ROS level and does not involve apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.