ArticleAnnals of biomedical engineering2010
The constitutive equation for membrane tether extraction.
Article in Annals of biomedical engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Biomechanics of Neutrophil Tethers.Life (Basel, Switzerland) · 2021Review
- Biomechanics of Borrelia burgdorferi Vascular Interactions.Cell reports · 2016Article
- Endothelial Surface Protrusion by a Point Force.Biophysical journal · 2016Article
- The properties of chondrocyte membrane reservoirs and their role in impact-induced cell death.Biophysical journal · 2013Article
- Tangential tether extraction and spontaneous tether retraction of human neutrophils.Biophysical journal · 2012Article
- Cell protrusions and tethers: a unified approach.Biophysical journal · 2011Article
- Biomechanics of leukocyte rolling.Biorheology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Membrane tethers or nanotubes play a critical role in a variety of cellular and subcellular processes such as leukocyte rolling and intercellular mass transport. The current constitutive equations that describe the relationship between the pulling force and the tether velocity during tether extraction have serious limitations. In this article, we propose a new phenomenological constitutive equation that captures all known characteristics of nanotube formation, including nonlinearity, nonzero threshold force, and possible negative tether velocity. We used tether extraction from endothelial cells as a prototype to illustrate how to obtain the material constants in the constitutive equation. With the micropipette aspiration technique, we measured tether pulling forces at both positive and negative tether velocities. We also determined the threshold force of 55 pN experimentally for the first time. This new constitutive equation unites two established ones and provides us a unified platform to better understand not only the physiological role of tether extraction during leukocyte rolling and intercellular or intracellular transport, but also the physics of membrane tether growth or retraction.
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Registered trials
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