Evidence map›Paper›PMID 20614218›Full record

ReviewSeminars in immunopathology2010

Cellular choreography in the germinal center: new visions from in vivo imaging.

Anja E Hauser, Steven M Kerfoot, Ann M Haberman

Abstract readReview
In one paragraph

Review in Seminars in immunopathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. B cells within germinal centers migrate preferentially from dark to light zone.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anja E HauserDeutsches Rheuma-Forschungszentrum (DRFZ), Berlin 10117, Germany.
Steven M Kerfoot
Ann M Haberman

Funding

Yale Rheumatic Diseases Research Core CenterP30AR053495 · NIAMS · YALE UNIVERSITY · PI SHLOMCHIK, WARREN D · 2007 to 2017
$7.0M
In vivo imaging of T and B cell interactions in germinal center initiationR01AI080850 · NIAID · YALE UNIVERSITY · PI HABERMAN, ANN M · 2009 to 2012
$1.6M
NIAID NIH HHS 1R01AI080850-01A1NIAID NIH HHS R01 AI080850NIAMS NIH HHS P30 AR053495
6 · The paper itself

Abstract

Germinal centers (GC) are large aggregates of proliferating B lymphocytes within follicles of lymphoid tissue that form during adaptive immune responses. GCs are the source of long-lived B cells that form the basis for pathogen-specific lifelong B cell immunity. The complex architecture of these structures includes subdomains that differ significantly in their stromal cell and T lymphocyte subset composition. In part due to their structural complexity and potential to generate some lymphomas, much interest and many theories about GC dynamics have emerged. Here, we review recent research employing in vivo imaging that has begun to untangle some of the mysteries.

Indexed as

AnimalsB-LymphocytesCell DifferentiationCell MovementCell ProliferationDendritic CellsGerminal CenterMiceMicroscopy, Fluorescence, MultiphotonT-Lymphocyte Subsets

Identifiers

PMID20614218
PMCPMC3659422

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.