ArticleLangenbeck's archives of surgery2011
Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models.
Article in Langenbeck's archives of surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- The effect of gabapentin and pregabalin on intestinal incision wound healing in rabbits.Veterinary world · 2015Article
- Local tissue ischemia is not necessary for suture-induced adhesion formation.Langenbeck's archives of surgery · 2013Article
- The effect of postoperative hyperbaric oxygen treatment on intra-abdominal adhesions in rats.International journal of molecular sciences · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of small intestinal serosal defects remains controversial. Non-closure of such defects is regarded as a risk factor of fistula formation or intestinal leakage, whereas defect closure with absorbable suture material is potentially associated with adhesion formation. The aim of our pilot study was to evaluate the influence of small intestinal serosal defect closure on peritoneal wound healing, leakage rate, and adhesion formation in a rabbit model.
methodsTwenty-two male rabbits were randomized into two groups. Following median laparotomy, a standardized small intestinal serosal defect with a diameter of 1 cm was performed. Either the defect was closed by two seromuscular 4/0 polyglactin single sutures (n = 11) or the defect was left open (n = 11). On postoperative day 14, all animals were sacrificed for morphological investigations. Complications and the rate of intestinal leakage were measured. The degree of adhesion formation was measured by computer-assisted planimetry.
resultsNo animal developed fistula formation or intestinal leakage. Eight (73%) animals of the closure group developed local peritoneal adhesions with a mean size of 39.7 ± 45 mm(2). No animal in the non-closure group revealed local peritoneal adhesions at the defect. However, two (18%) animals in the non-closure group developed peritoneal adhesions distant to the defect with a mean size of 3.5 ± 9 mm(2). Comparing both groups, the size of peritoneal adhesions was significantly higher in the closure group (p = 0.013).
conclusionsClosure of isolated serosal injuries with resorbable suture material was associated with an adhesion formation in distressing certainty, whereas no leakage or fistula formation could be observed at all. Further studies are needed to clarify the impact of serosal defect closure in particular on leakage rate and fistula formation, e.g., with pre-existing adhesions, in case of multiple serosal injuries or with a pre-existing peritonitis.
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