ArticlePloS one2010
Immune responses elicited in tertiary lymphoid tissues display distinctive features.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Lymphatic Reconstruction in Kidney Allograft Aggravates Chronic Rejection by Promoting Alloantigen Presentation.Frontiers in immunology · 2021Article
- B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats.International journal of molecular sciences · 2020Article
- Novel histopathologic predictors for renal outcomes in crescentic glomerulonephritis.PloS one · 2020Article
- Targeting B Cells and Plasma Cells in Glomerular Diseases: Translational Perspectives.Journal of the American Society of Nephrology : JASN · 2018Review
- Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection.The Journal of clinical investigation · 2018Article
- Establishment of a rat and guinea pig aortic interposition graft model reveals model-specific patterns of intimal hyperplasia.Journal of vascular surgery · 2016Review
- Potential of Cells and Cytokines/Chemokines to Regulate Tertiary Lymphoid Structures in Human Diseases.Immune network · 2016Review
- Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- B Cells, Antibodies, and More.Clinical journal of the American Society of Nephrology : CJASN · 2016Review
- Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation.Frontiers in immunology · 2016Review
- Gel-Trapped Lymphorganogenic Chemokines Trigger Artificial Tertiary Lymphoid Organs and Mount Adaptive Immune Responses In Vivo.Frontiers in immunology · 2016Article
- Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs.Frontiers in immunology · 2016Review
- Once Upon a Time: The Adaptive Immune Response in Atherosclerosis--a Fairy Tale No More.Molecular medicine (Cambridge, Mass.) · 2015Review
- Recent advances in renal transplantation: antibody-mediated rejection takes center stage.F1000prime reports · 2015Review
- Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Effector mechanisms of rejection.Cold Spring Harbor perspectives in medicine · 2013Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the rat aortic interposition model in which a TLT has been evidenced in the adventitia of chronically rejected allografts one month after transplantation. The immune responses elicited in adventitial TLT and those taking place in spleen and draining lymph nodes (LN) were compared in terms of antibody production, T cell activation and repertoire perturbations. The anti-MHC humoral response was more intense and more diverse in TLT. This difference was associated with an increased percentage of activated CD4+ T cells and a symmetric reduction of regulatory T cell subsets. Moreover, TCR repertoire perturbations in TLT were not only increased and different from the common pattern observed in spleen and LN but also "stochastic," since each recipient displayed a specific pattern. We propose that the abnormal activation of CD4+ T cells promotes the development of an exaggerated pathogenic immune humoral response in TLT. Preliminary findings suggest that this phenomenon i) is due to a defective immune regulation in this non-professional inflammatory-induced lymphoid tissue, and ii) also occurs in human chronically rejected grafts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.