ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Sex-dependent antipsychotic capacity of 17β-estradiol in the latent inhibition model: a typical antipsychotic drug in both sexes, atypical antipsychotic drug in males.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 37 citations in OpenAlex.
- Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders.Molecular biology reports · 2024Review
- Stratification by Sex and Hormone Level When Contrasting Men and Women in Schizophrenia Trials Will Improve Personalized Treatment.Journal of personalized medicine · 2021Review
- Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders.Translational psychiatry · 2020Article
- Sex-dependent mental illnesses and mitochondria.Schizophrenia research · 2017Review
- PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia.Scientific reports · 2017Article
- Sex differences in addiction.Dialogues in clinical neuroscience · 2016Review
- Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice.Psychopharmacology · 2015Article
- Can the neurodevelopmental theory account for sex differences in schizophrenia across the life span?Journal of psychiatry & neuroscience : JPN · 2015Article
- Sex differences in animal models of psychiatric disorders.British journal of pharmacology · 2014Review
- Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment.Frontiers in behavioral neuroscience · 2013Article
- Sex steroids and schizophrenia.Reviews in endocrine & metabolic disorders · 2012Review
- Role of estrogen treatment in the management of schizophrenia.CNS drugs · 2012Review
- Estradiol modulates effort-based decision making in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- The role of oestrogen and other hormones in the pathophysiology and treatment of schizophrenia.Schizophrenia research and treatment · 2012Article
- The role of estrogen and testosterone in female rats in behavioral models of relevance to schizophrenia.Psychopharmacology · 2012Article
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2 authors at 1 institution in 1 country.
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Abstract
The estrogen hypothesis of schizophrenia suggests that estrogen is a natural neuroprotector in women and that exogenous estrogen may have antipsychotic potential, but results of clinical studies have been inconsistent. We have recently shown using the latent inhibition (LI) model of schizophrenia that 17β-estradiol exerts antipsychotic activity in ovariectomized (OVX) rats. The present study sought to extend the characterization of the antipsychotic action of 17β-estradiol (10, 50 and 150 μg/kg) by testing its capacity to reverse amphetamine- and MK-801-induced LI aberrations in gonadally intact female and male rats. No-drug controls of both sexes showed LI, ie, reduced efficacy of a previously non-reinforced stimulus to gain behavioral control when paired with reinforcement, if conditioned with two but not five tone-shock pairings. In both sexes, amphetamine (1 mg/kg) and MK-801 (50 μg/kg) produced disruption (under weak conditioning) and persistence (under strong conditioning) of LI, modeling positive and negative/cognitive symptoms, respectively. 17β-estradiol at 50 and 150 μg/kg potentiated LI under strong conditioning and reversed amphetamine-induced LI disruption in both males and females, mimicking the action of typical and atypical antipsychotic drugs (APDs) in the LI model. 17β-estradiol also reversed MK-induced persistent LI, an effect mimicking atypical APDs and NMDA receptor enhancers, but this effect was observed in males and OVX females but not in intact females. These findings indicate that in the LI model, 17β-estradiol exerts a clear-cut antipsychotic activity in both sexes and, remarkably, is more efficacious in males and OVX females where it also exerts activity considered predictive of anti-negative/cognitive symptoms.
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